Myog - myogenin Gene

Mus musculus

Also known as myo; MYF4; bHLHc3

Gene ID: 17928 | Gene type: protein coding

About Myog

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of cell differentiation; and regulation of muscle adaptation. Acts upstream of or within several processes, including cellular response to lithium ion; cellular response to tumor necrosis factor; and skeletal muscle fiber development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and musculature. Orthologous to human MYOG (myogenin). [provided by Alliance of Genome Resources, Apr 2022]

Myog Products(1)

mRNA	Protein	Name
NM_031189.2	NP_112466.1	myogenin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	15706034	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17531403	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12486129	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	15706034	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10835421	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19783823	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	22847234	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20399744	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7973707	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22638570	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15706034	MGI
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	15322112	MGI
acts upstream of or within cellular response to lithium ion	IDA IDA: Inferred from direct assay	15673614	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	24349514	MGI
involved in muscle cell differentiation	IDA IDA: Inferred from direct assay	10652346	MGI
acts upstream of or within muscle organ development	IGI IGI: Inferred from genetic interaction	8587605	MGI
acts upstream of or within myotube differentiation	IGI IGI: Inferred from genetic interaction	22106411	MGI
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	22847234	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	8587605	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17904117	MGI
involved in positive regulation of muscle atrophy	IMP IMP: Inferred from mutant phenotype	21465538	MGI
involved in positive regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	22847234	MGI
involved in positive regulation of myotube differentiation	IDA IDA: Inferred from direct assay	22847234	MGI
involved in positive regulation of skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	8393145	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8760303	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15706034	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20399744	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22638570	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8393145	MGI
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	22847234	MGI
involved in regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	21465538	MGI
involved in regulation of skeletal muscle satellite cell proliferation	IMP IMP: Inferred from mutant phenotype	21465538	MGI
involved in response to denervation involved in regulation of muscle adaptation	IDA IDA: Inferred from direct assay	21465538	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	8393145	MGI
acts upstream of or within skeletal muscle tissue development	IDA IDA: Inferred from direct assay	14762206	MGI
involved in striated muscle atrophy	IMP IMP: Inferred from mutant phenotype	21465538	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16554364	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myogenin

MYOD1-related protein

Myog Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Myog	P12979	Mef2a	Mus musculus	Q60929	Anti Bait CoIP	7973707

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08959	MYOG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20301	Myog Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26809	Myog Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myog	NCBI	NCBI:4656

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