Mt3 - metallothionein 3 Gene

Mus musculus

Also known as Mt-3

Gene ID: 17751 | Gene type: protein coding

About Mt3

Summary

Enables zinc ion binding activity. Involved in several processes, including negative regulation of cell death; regulation of cellular macromolecule biosynthetic process; and transition metal ion homeostasis. Acts upstream of or within cellular metal ion homeostasis and negative regulation of neurogenesis. Located in synaptic vesicle. Is expressed in brain; decidua; ganglia; ventral grey horn; and ventricular layer. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3). [provided by Alliance of Genome Resources, Apr 2022]

Mt3 Products(1)

mRNA	Protein	Name
NM_013603.2	NP_038631.1	metallothionein-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metal ion binding	IDA IDA: Inferred from direct assay	12130647	MGI
enables zinc ion binding	IDA IDA: Inferred from direct assay	7931547	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in detoxification of cadmium ion	IMP IMP: Inferred from mutant phenotype	20371971	MGI
involved in energy reserve metabolic process	IMP IMP: Inferred from mutant phenotype	21726645	MGI
acts upstream of or within intracellular monoatomic cation homeostasis	IDA IDA: Inferred from direct assay	12130647	MGI
involved in intracellular zinc ion homeostasis	IDA IDA: Inferred from direct assay	20544854	MGI
involved in intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	21726645	MGI
involved in leptin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21726645	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19635467	MGI
acts upstream of or within negative regulation of neurogenesis	IDA IDA: Inferred from direct assay	12130647	MGI
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	21359432	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21726645	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21726645	MGI
involved in positive regulation of oxygen metabolic process	IMP IMP: Inferred from mutant phenotype	21726645	MGI
involved in regulation of response to food	IMP IMP: Inferred from mutant phenotype	21726645	MGI
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19635467	MGI
involved in sequestering of metal ion	IMP IMP: Inferred from mutant phenotype	20371971	MGI
involved in zinc ion transport	IDA IDA: Inferred from direct assay	21359432	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in synaptic vesicle	IDA IDA: Inferred from direct assay	7931547	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

metallothionein-3

GIF	MT-III
growth inhibitory factor	metallothionein-III

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128206	I3MT-3	Inhibitor	99.98%	Unkown
HY-P5846	Muscarinic toxin 3	Antagonist	/	Unkown
HY-RS08744	MT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19565	Mt3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26061	Mt3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mt3	NCBI	NCBI:4504

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