Mpeg1 - macrophage expressed gene 1 Gene

Mus musculus

Also known as P-2; MPS1; Mpg-1

Gene ID: 17476 | Gene type: protein coding

About Mpeg1

Summary

Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and pore formation in membrane of Other organism. Located in phagocytic vesicle. Is expressed in several structures, including blood vessel; central nervous system; developing vasculature of reproductive system; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1). [provided by Alliance of Genome Resources, Apr 2022]

Mpeg1 Products(2)

mRNA	Protein	Name
NM_001374668.1	NP_001361597.1	macrophage-expressed gene 1 protein precursor
NM_010821.2	NP_034951.2	macrophage-expressed gene 1 protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables pore-forming activity	IDA IDA: Inferred from direct assay	26402460	MGI
enables wide pore channel activity	IDA IDA: Inferred from direct assay	32064340	MGI

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in antibacterial innate immune response	IMP IMP: Inferred from mutant phenotype	35471730	MGI
involved in antibacterial innate immune response	IMP IMP: Inferred from mutant phenotype	26402460	MGI
involved in antigen processing and presentation of exogenous peptide antigen	IDA IDA: Inferred from direct assay	35471730	MGI
involved in antigen processing and presentation of exogenous peptide antigen via MHC class I	IDA IDA: Inferred from direct assay	37347855	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	23257510	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	23257510	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	26402460	MGI
involved in dendritic cell antigen processing and presentation	IDA IDA: Inferred from direct assay	37347855	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	26402460	MGI
is active in endolysosome	IDA IDA: Inferred from direct assay	35471730	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	26402460	MGI
is active in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	37347855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

macrophage-expressed gene 1 protein

macrophage gene 1 protein

perforin-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114512	m-PEG1-NHS ester		≥95.0%	Unkown
HY-P10392AF	fStAx-35R TFA	Inhibitor	97.35%	Unkown
HY-RS08610	MPEG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20991	Mpeg1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27508	Mpeg1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mpeg1	NCBI	NCBI:219972

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