Mitf - melanogenesis associated transcription factor Gene

Mus musculus

Also known as Wh; bw; mi; vit; BCC2; Bhlhe32; Gsfbcc2; Vitiligo

Gene ID: 17342 | Gene type: protein coding

About Mitf

Summary

This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]

Mitf Products(12)

mRNA	Protein	Name
NM_001113198.2	NP_001106669.1	microphthalmia-associated transcription factor isoform 1
NM_001178049.2	NP_001171520.1	microphthalmia-associated transcription factor isoform 3
NM_001410051.1	NP_001396980.1	microphthalmia-associated transcription factor isoform 4
NM_001410052.1	NP_001396981.1	microphthalmia-associated transcription factor isoform 5
NM_001410053.1	NP_001396982.1	microphthalmia-associated transcription factor isoform 6
NM_001410054.1	NP_001396983.1	microphthalmia-associated transcription factor isoform 7
NM_001410055.1	NP_001396984.1	microphthalmia-associated transcription factor isoform 8
NM_001410056.1	NP_001396985.1	microphthalmia-associated transcription factor isoform 9
NM_001410057.1	NP_001396986.1	microphthalmia-associated transcription factor isoform 10
NM_001410058.1	NP_001396987.1	microphthalmia-associated transcription factor isoform 11
NM_001410059.1	NP_001396988.1	microphthalmia-associated transcription factor isoform 12 precursor
NM_008601.4	NP_032627.1	microphthalmia-associated transcription factor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14575687	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15716956	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12235125	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15729346	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	23207919	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	23207919	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15716956	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15729346	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17442941	MGI
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	23207919	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	12235125	MGI
acts upstream of or within bone remodeling	IMP IMP: Inferred from mutant phenotype	12086670	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	15576400	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	9199364	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	15576400	MGI
acts upstream of melanocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	12086670	MGI
acts upstream of or within melanocyte differentiation	IGI IGI: Inferred from genetic interaction	12086670	MGI
acts upstream of or within melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	2379821	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12086670	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	12086670	MGI
acts upstream of or within pigmentation	IGI IGI: Inferred from genetic interaction	12086670	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	2379821	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14575687	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17442941	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15304486	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15729346	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24769727	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12235125	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12086670	MGI
acts upstream of or within regulation of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	11930005	MGI
acts upstream of or within regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	11930005	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12235125	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23207919	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12235125	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microphthalmia-associated transcription factor

black eyed white

microphtalmia-associated transcription factor

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-113337	Ap4A	Inducer	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101464	ML329	Inhibitor	≥98.0%	Unkown
HY-N1481	Methyl linoleate	Inhibitor	≥98.0%	Unkown
HY-156483	TT-012		99.76%	Unkown
HY-113337A	Ap4A tetraammonium	Inducer	≥97.0%	Unkown
HY-D0168	Orcinol		99.97%	Unkown
HY-N12267	N,N′-Diferuloylputrescine	Inhibitor	≥97.0%	Unkown
HY-N2204	Swertiajaponin	Inhibitor	99.84%	Unkown
HY-169363	PDL1 degrader-2		99.41%	Unkown
HY-N2983	Cajanin	Inhibitor	99.96%	Unkown
HY-N6901	Luteolin 7-sulfate		≥95.0%	Unkown
HY-RS08467	MITF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-159917	PPL agonist-1		/	Unkown
HY-N0113A	Hordenine sulfate		/	Unkown
HY-N10016	Chlorogenic acid butyl ester	Inhibitor	/	Unkown
HY-N10437	6-Acetylnimbandiol	Inhibitor	/	Unkown
HY-N3810	ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Inhibitor	/	Unkown
HY-P4497	Prolylserine		/	Unkown
HY-RS16290	Mitf Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N10623	5-epi-Arvestonate A	Activator	/	Unkown
HY-RS23266	Mitf Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mitf	NCBI	NCBI:4286

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