Mapkapk5 - MAP kinase-activated protein kinase 5 Gene

Mus musculus

Also known as MK5; PRAK

Gene ID: 17165 | Gene type: protein coding

About Mapkapk5

Summary

Enables mitogen-activated protein kinase binding activity; p53 binding activity; and protein serine/threonine kinase activity. Involved in Ras protein signal transduction; negative regulation of TOR signaling; and stress-induced premature senescence. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin Cytoskeleton. Part of protein-containing complex. Is expressed in brain; embryo; and lung. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk5 Products(1)

mRNA	Protein	Name
NM_010765.2	NP_034895.1	MAP kinase-activated protein kinase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	15577943	MGI
enables p53 binding	IDA IDA: Inferred from direct assay	17254968	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15538386	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	15538386	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15577943	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	17254968	MGI
involved in negative regulation of TOR signaling	IDA IDA: Inferred from direct assay	21336308	MGI
acts upstream of or within positive regulation of dendritic spine development	IGI IGI: Inferred from genetic interaction	22508986	MGI
acts upstream of or within positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	22508986	MGI
involved in stress-induced premature senescence	IMP IMP: Inferred from mutant phenotype	17254968	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15538386	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15538386	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	22508986	MGI
located in septin cytoskeleton	IDA IDA: Inferred from direct assay	22508986	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MAP kinase-activated protein kinase 5

MAPK-activated protein kinase 5	MAPKAP kinase 5
MAPKAPK-5

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-RS08135	MAPKAPK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17135	Mapkapk5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23581	Mapkapk5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapkapk5	NCBI	NCBI:8550

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