2. Gene
  3. Mlph - melanophilin Gene

Mlph - melanophilin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ln; l1Rk3; Slac-2a; D1Wsu84e; l(1)-3Rk; 2210418F23Rik; 5031433I09Rik

Gene ID: 171531 | Gene type: protein coding

About Mlph

Summary

Enables cytoskeletal protein binding activity and small GTPase binding activity. Acts upstream of or within melanocyte differentiation; melanosome localization; and protein targeting. Located in Cytoskeleton and melanosome. Part of unconventional Myosin complex. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Griscelli syndrome type 3. Orthologous to human MLPH (melanophilin). [provided by Alliance of Genome Resources, Apr 2022]

Mlph Products(1)

mRNA Protein Name
NM_053015.3 NP_443748.2 melanophilin
Protein Preferred Names Protein Names

melanophilin

exophilin-3

leaden protein

slaC2-a

slp homolog lacking C2 domains a

synaptotagmin-like protein 2a

Mlph Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Mlph Q91V27 Rab27a Mus musculus Q9ERI2
Anti Tag CoIP
18940604
Intra
Mlph Q91V27 Rab27a Mus musculus Q9ERI2
CoIP
11773082
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08501 MLPH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlph NCBI NCBI:79083