Gchfr - GTP cyclohydrolase I feedback regulator Gene

Rattus norvegicus

Gene ID: 171128 | Gene type: protein coding

About Gchfr

Summary

Enables several functions, including GTP cyclohydrolase binding activity; GTP-dependent protein binding activity; and amino acid binding activity. Involved in negative regulation of GTP cyclohydrolase I activity and protein-containing complex assembly. Part of protein-containing complex. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator). [provided by Alliance of Genome Resources, Apr 2022]

Gchfr Products(1)

mRNA	Protein	Name
NM_133595.2	NP_598279.1	GTP cyclohydrolase 1 feedback regulatory protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP cyclohydrolase I regulator activity	IDA IDA: Inferred from direct assay	8702680	RGD
enables GTP cyclohydrolase binding	IDA IDA: Inferred from direct assay	8702680	RGD
enables GTP cyclohydrolase binding	IPI IPI: Inferred from physical interaction	9685352	RGD
enables GTP-dependent protein binding	IPI IPI: Inferred from physical interaction	9685352	RGD
enables amino acid binding	IDA IDA: Inferred from direct assay	11818540	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	11580249	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11818540	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9685352	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15448133	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	9685352	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of intracellular protein-containing complex	IDA IDA: Inferred from direct assay	8702680	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11818540	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GTP cyclohydrolase 1 feedback regulatory protein

GFRP	GTP cyclohydrolase I feedback regulatory protein
p35

Gchfr Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gchfr	P70552	Gch1	Rattus norvegicus	P22288	X-Ray Diffraction	11818540

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05328	GCHFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gchfr	NCBI	NCBI:2644

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