Sp7 - Sp7 transcription factor 7 Gene

Mus musculus

Also known as C22; Osx; 6430578P22Rik

Gene ID: 170574 | Gene type: protein coding

About Sp7

Summary

Enables DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within osteoblast differentiation and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; facial prominence mesenchyme; genitourinary system; jaw; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp7 Products(4)

mRNA	Protein	Name
NM_001348205.1	NP_001335134.1	transcription factor Sp7 isoform 2
NM_130458.4	NP_569725.1	transcription factor Sp7 isoform 1
NM_001348205.1	NP_001335134.1	transcription factor Sp7 isoform 2
NM_130458.4	NP_569725.1	transcription factor Sp7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DEAD/H-box RNA helicase binding	IPI IPI: Inferred from physical interaction	17303075	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	11792318	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16041384	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16041384	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19927124	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cementum mineralization	IDA IDA: Inferred from direct assay	31059863	MGI
involved in cementum mineralization	IGI IGI: Inferred from genetic interaction	31059863	MGI
involved in cementum mineralization	IMP IMP: Inferred from mutant phenotype	31059863	MGI
involved in diphosphate metabolic process	IMP IMP: Inferred from mutant phenotype	31059863	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	31059863	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	31059863	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	11792318	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16041384	MGI
involved in regulation of hydrolase activity	IMP IMP: Inferred from mutant phenotype	31059863	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11792318	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22886301	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11792318	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor Sp7

zinc finger protein osterix

Sp7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Sp7	Q8VI67	RIOX1	Homo sapiens	Q9H6W3	Anti Tag CoIP	19927124
Cross	Sp7	Q8VI67	RIOX1	Homo sapiens	Q9H6W3	Pull Down	19927124

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15977	(S)-P7C3-OMe		/	Unkown
HY-162568	7-tert-Butylfascaplysin		/	Unkown
HY-RS13610	SP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17939	Sp7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24410	Sp7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sp7	NCBI	NCBI:121340
Rattus norvegicus	Sp7	NCBI	NCBI:300260

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