Loxl3 - lysyl oxidase-like 3 Gene

Mus musculus

Also known as Lor2; Loxl2

Gene ID: 16950 | Gene type: protein coding

About Loxl3

Summary

Enables fibronectin binding activity and protein-lysine 6-oxidase activity. Involved in several processes, including fibronectin fibril organization; negative regulation of T-helper 17 cell lineage commitment; and peptidyl-lysine oxidation. Located in extracellular space. Is expressed in several structures, including alimentary system; connective tissue; limb mesenchyme; sensory organ; and skeleton. Orthologous to human LOXL3 (Lysyl Oxidase like 3). [provided by Alliance of Genome Resources, Apr 2022]

Loxl3 Products(1)

mRNA	Protein	Name
NM_013586.5	NP_038614.2	lysyl oxidase homolog 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibronectin binding	IDA IDA: Inferred from direct assay	26954549	MGI
enables protein-lysine 6-oxidase activity	IDA IDA: Inferred from direct assay	26954549	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in fibronectin fibril organization	IMP IMP: Inferred from mutant phenotype	26954549	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	28065600	MGI
involved in lung development	IMP IMP: Inferred from mutant phenotype	27645581	MGI
involved in negative regulation of T-helper 17 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	28065600	MGI
involved in peptidyl-lysine oxidation	IDA IDA: Inferred from direct assay	26954549	MGI
involved in positive regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26954549	MGI
involved in roof of mouth development	IMP IMP: Inferred from mutant phenotype	26307084	MGI
involved in somite development	IMP IMP: Inferred from mutant phenotype	26954549	MGI
involved in spinal cord development	IMP IMP: Inferred from mutant phenotype	26307084	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	26954549	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lysyl oxidase homolog 3

lysyl oxidase-like 2	lysyl oxidase-like protein 3
lysyl oxidase-related protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114286A	PXS-5153A monohydrochloride	Inhibitor	99.67%	Unkown
HY-151499A	PXS-6302 hydrochloride	Inhibitor	99.83%	Unkown
HY-114286	PXS-5153A	Inhibitor	/	Unkown
HY-151498A	PXS-4787 hydrochloride	Inhibitor	99.71%	Unkown
HY-151498	PXS-4787	Inhibitor	/	Unkown
HY-151499	PXS-6302	Inhibitor	/	Unkown
HY-RS07743	LOXL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21632	Loxl3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Loxl3	NCBI	NCBI:84695

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