2. Gene
  3. Lck - lymphocyte protein tyrosine kinase Gene

Lck - lymphocyte protein tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Lsk; Lskt; Hck-3; p56Lck; p56

Gene ID: 16818 | Gene type: protein coding

About Lck

Summary

Enables several functions, including CD4 receptor binding activity; protein antigen binding activity; and protein Phosphatase binding activity. Involved in release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of T cell differentiation. Located in cell-cell junction. Colocalizes with plasma membrane. Is expressed in several structures, including 2-cell stage embryo; nervous system; neural ectoderm; sensory organ; and thymus primordium. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human Lck (Lck proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lck Products(3)

mRNA Protein Name
NM_001162432.1 NP_001155904.1 proto-oncogene tyrosine-protein kinase LCK isoform a
NM_001162433.1 NP_001155905.1 proto-oncogene tyrosine-protein kinase LCK isoform b
NM_010693.3 NP_034823.1 proto-oncogene tyrosine-protein kinase LCK isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables CD4 receptor binding IPI
IPI: Inferred from physical interaction
3262426 MGI
enables protein antigen binding IPI
IPI: Inferred from physical interaction
21245484 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7486703 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
24714587 MGI
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
16709819 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7499277 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
21487392 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
7499277 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
9177270 MGI
acts upstream of gamma-delta T cell differentiation IMP
IMP: Inferred from mutant phenotype
7807014 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
7499277 MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation IMP
IMP: Inferred from mutant phenotype
7807014 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
21357543 MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
11254359 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
8175795 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
9169414 MGI
acts upstream of or within regulation of T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
14752163 MGI
acts upstream of or within regulation of regulatory T cell differentiation IGI
IGI: Inferred from genetic interaction
21245484 MGI
involved in release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
1505025 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
3262426 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase LCK

leukocyte C-terminal Src kinase

lymphocyte cell-specific protein-tyrosine kinase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-157442 GLPG3312 Inhibitor 98.57% Phase 1
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132166 Velzatinib Inhibitor 99.47% Unkown
HY-13561 AZM475271 Inhibitor 99.89% Unkown
HY-112291 SB 220025 Inhibitor 99.90% Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-118105 RK-20448 Inhibitor 99.38% Unkown
HY-175281 SJ11646 Degrader / Unkown
HY-175463 LCK degrader-2 Degrader / Unkown
HY-163278 Lck-IN-2 Inhibitor / Unkown
HY-175193 N-Deshydroxyethyl Dasatinib-C3-NH2 Inhibitor / Unkown
HY-176194 Antifibrotic agent 1 Inhibitor / Unkown
HY-120622 BMS-243117 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lck NCBI NCBI:3932