Itga5 - integrin alpha 5 (fibronectin receptor alpha) Gene

Mus musculus

Also known as Fnra; VLA5; Cd49e

Gene ID: 16402 | Gene type: protein coding

About Itga5

Summary

The product of this gene belongs to the Integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the Integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and Integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Itga5 Products(2)

mRNA	Protein	Name
NM_001314041.1	NP_001300970.1	integrin alpha-5 isoform 2
NM_010577.4	NP_034707.5	integrin alpha-5 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	8601592	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12867986	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	36812915	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell-cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	8557754	MGI
acts upstream of or within cell-substrate junction assembly	IDA IDA: Inferred from direct assay	12867986	MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	8557754	MGI
acts upstream of or within leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8557754	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	12904471	MGI
involved in regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	19460962	MGI
involved in response to muscle activity	IDA IDA: Inferred from direct assay	36812915	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12189152	MGI
located in cell surface	IDA IDA: Inferred from direct assay	8306881	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12189152	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12189152	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8557754	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	36812915	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12189152	MGI
located in synapse	IDA IDA: Inferred from direct assay	12904471	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin alpha-5

CD49 antigen-like family member E	fibronectin receptor alpha polypeptide
fibronectin receptor subunit alpha	integrin alpha-F

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06952	ITGA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16901	Itga5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23343	Itga5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itga5	NCBI	NCBI:3678

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