2. Gene
  3. Iapp - islet amyloid polypeptide Gene

Iapp - islet amyloid polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DAP

Gene ID: 15874 | Gene type: protein coding

About Iapp

Summary

Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of bone resorption; negative regulation of cell differentiation; and sensory perception of pain. Located in extracellular space and neuronal cell body. Is expressed in embryo; pancreas; pancreas primordium; and pancreas trunk epithelium. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide). [provided by Alliance of Genome Resources, Apr 2022]

Iapp Products(1)

mRNA Protein Name
NM_010491.2 NP_034621.1 islet amyloid polypeptide precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of bone resorption IMP
IMP: Inferred from mutant phenotype
14970190 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
14970190 MGI
acts upstream of or within negative regulation of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
14970190 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
14970190 MGI
acts upstream of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
14970190 MGI
acts upstream of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
14970190 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
9838101 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
17693256 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

islet amyloid polypeptide

amylin

diabetes-associated peptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1871A Amylin (IAPP), feline TFA 98.75% Unkown
HY-P1871 Amylin (IAPP), feline / Unkown
HY-P3926 Amylin (8-37) (human) / Unkown
HY-P4767 Amylin (1-13) (human) Ligand / Unkown
HY-RS06506 IAPP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17689 Iapp Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24151 Iapp Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Iapp NCBI NCBI:3375