Htr2c - 5-hydroxytryptamine (serotonin) receptor 2C Gene

Mus musculus

Also known as SR1; 5HT1c; Htr1c; 5-HT1C; 5-HT2C; 5-HT-1C; 5-HT-2C; 5-HT2cR; 5-HTR2C

Gene ID: 15560 | Gene type: protein coding

About Htr2c

Summary

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate Phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter Amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of Phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]

Htr2c Products(2)

mRNA	Protein	Name
NM_001411391.1	NP_001398320.1	5-hydroxytryptamine receptor 2C isoform 2
NM_008312.4	NP_032338.3	5-hydroxytryptamine receptor 2C precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	21835345	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16914526	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral fear response	IMP IMP: Inferred from mutant phenotype	17451451	MGI
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	7700379	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21835345	MGI
involved in phospholipase C-activating serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21835345	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	8626447	MGI
acts upstream of or within positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20719859	MGI
involved in regulation of appetite	IMP IMP: Inferred from mutant phenotype	21048120	MGI
involved in regulation of corticotropin-releasing hormone secretion	IMP IMP: Inferred from mutant phenotype	17451451	MGI
involved in regulation of nervous system process	IMP IMP: Inferred from mutant phenotype	17596444	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 2C

5-HT2C receptor	5-hydroxytryptamine receptor 1C
serotonin receptor 2C

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06469	HTR2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20957	Htr2c Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27474	Htr2c Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr2c	NCBI	NCBI:3358

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