Hoxa2 - homeobox A2 Gene

Mus musculus

Also known as HOX1.11; Hox-1.11

Gene ID: 15399 | Gene type: protein coding

About Hoxa2

Summary

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013]

Hoxa2 Products(1)

mRNA	Protein	Name
NM_010451.2	NP_034581.1	homeobox protein Hox-A2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15634706	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15634706	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15634706	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	9367425	MGI
acts upstream of or within brain segmentation	IMP IMP: Inferred from mutant phenotype	9367425	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	7903600	MGI
acts upstream of or within cell fate determination	IMP IMP: Inferred from mutant phenotype	16221728	MGI
acts upstream of or within cellular response to retinoic acid	IDA IDA: Inferred from direct assay	23723417	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	10230789	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	10230789	MGI
involved in embryonic skeletal system development	IDA IDA: Inferred from direct assay	25889273	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	15634706	MGI
acts upstream of or within embryonic viscerocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	16221728	MGI
acts upstream of or within middle ear morphogenesis	IGI IGI: Inferred from genetic interaction	15634706	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15861402	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	9367425	MGI
involved in muscle structure development	IDA IDA: Inferred from direct assay	25889273	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	18164701	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18164701	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	21324897	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15634706	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	18164701	MGI
acts upstream of or within osteoblast development	IGI IGI: Inferred from genetic interaction	16751105	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	7903600	MGI
involved in pharyngeal system development	IDA IDA: Inferred from direct assay	25889273	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18787068	MGI
acts upstream of or within rhombomere 2 development	IMP IMP: Inferred from mutant phenotype	7508007	MGI
acts upstream of or within rhombomere 3 development	IGI IGI: Inferred from genetic interaction	7508007	MGI
acts upstream of or within rhombomere 3 morphogenesis	IMP IMP: Inferred from mutant phenotype	10230789	MGI
acts upstream of or within segment specification	IMP IMP: Inferred from mutant phenotype	9367425	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10536059	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Hox-A2

homeo box A2

homeobox protein Hox-1.11

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06297	HOXA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22557	Hoxa2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hoxa2	NCBI	NCBI:3199

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