Nr4a1 - nuclear receptor subfamily 4, group A, member 1 Gene

Mus musculus

Also known as Hmr; N10; TR3; Gfrp; Hbr1; NP10; TIS1; GFRP1; Hbr-1; NGFIB; nur77; NGFI-B; NUR77-1; NUR77-2

Gene ID: 15370 | Gene type: protein coding

About Nr4a1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in cellular response to corticotropin-releasing hormone stimulus; fat cell differentiation; and negative regulation of cell cycle. Acts upstream of or within several processes, including positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; and skeletal muscle cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including bone; genitourinary system; hemolymphoid system; nervous system; and submandibular gland primordium. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr4a1 Products(6)

mRNA	Protein	Name
NM_001411253.1	NP_001398182.1	nuclear receptor subfamily 4 group A member 1
NM_001411254.1	NP_001398183.1	nuclear receptor subfamily 4 group A member 1
NM_010444.3	NP_034574.1	nuclear receptor subfamily 4 group A member 1
NM_001411253.1	NP_001398182.1	nuclear receptor subfamily 4 group A member 1
NM_001411254.1	NP_001398183.1	nuclear receptor subfamily 4 group A member 1
NM_010444.3	NP_034574.1	nuclear receptor subfamily 4 group A member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18292087	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9155013	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	37001519	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	18388149	MGI
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	37001519	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8961274	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8961274	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	17434920	MGI
involved in cellular response to corticotropin-releasing hormone stimulus	IDA IDA: Inferred from direct assay	10523643	MGI
involved in detection of lipopolysaccharide	IDA IDA: Inferred from direct assay	37001519	MGI
involved in fat cell differentiation	IDA IDA: Inferred from direct assay	18945812	MGI
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	18945812	MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12815108	MGI
involved in non-canonical inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	37001519	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8961274	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	14657025	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8961274	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15155786	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	28775000	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15155786	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	30134173	MGI
located in cytosol	IDA IDA: Inferred from direct assay	37001519	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12815108	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9155013	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor subfamily 4 group A member 1

hormone receptor	nuclear hormone receptor NUR/77
nuclear protein N10	orphan nuclear receptor HMR

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1624	Teduglutide	Activator	99.94%	Unkown
HY-P1624A	Teduglutide TFA	Activator	/	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2148	Cytosporone B	Agonist	99.23%	Unkown
HY-112055	DIM-C-pPhOH		99.05%	Unkown
HY-112056	DIM-C-pPhCO2Me		99.47%	Unkown
HY-159779	NR-V04	Degrader	96.71%	Unkown
HY-160498	Amoitone B	Agonist	98.50%	Unkown
HY-RS09550	NR4A1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS16573	Nr4a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23006	Nr4a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr4a1	NCBI	NCBI:3164

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