Hmga2 - high mobility group AT-hook 2 Gene

Mus musculus

Also known as pg; Hmgic; pygmy; HMGI-C; 9430083A20Rik

Gene ID: 15364 | Gene type: protein coding

About Hmga2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow. Acts upstream of or within several processes, including animal organ development; negative regulation of astrocyte differentiation; and positive regulation of cell population proliferation. Located in nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian Cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Apr 2022]

Hmga2 Products(2)

mRNA	Protein	Name
NM_001347170.1	NP_001334099.1	high mobility group protein HMGI-C isoform 2
NM_010441.3	NP_034571.1	high mobility group protein HMGI-C isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: Inferred from direct assay	16109425	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14668482	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	7958830	MGI
acts upstream of or within adrenal gland development	IMP IMP: Inferred from mutant phenotype	7958830	MGI
acts upstream of astrocyte differentiation	IDA IDA: Inferred from direct assay	18640244	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18957199	MGI
acts upstream of or within cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	18957199	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24661562	MGI
acts upstream of or within fat pad development	IGI IGI: Inferred from genetic interaction	10742101	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	7651535	MGI
acts upstream of or within lung epithelium development	IMP IMP: Inferred from mutant phenotype	24661562	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	7958830	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	24728959	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24661562	MGI
acts upstream of or within negative regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	18640244	MGI
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	23072816	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	504232	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23072816	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18957199	MGI
involved in positive regulation of cell proliferation in bone marrow	IMP IMP: Inferred from mutant phenotype	23072816	MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24661562	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	7651535	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15225648	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	5051369	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18957199	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24661562	MGI
involved in regulation of cell cycle process	IDA IDA: Inferred from direct assay	14645522	MGI
acts upstream of or within regulation of growth hormone secretion	IMP IMP: Inferred from mutant phenotype	504232	MGI
acts upstream of or within regulation of peptide hormone secretion	IMP IMP: Inferred from mutant phenotype	504232	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	18957199	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18957199	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	12032866	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18957199	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	12032866	MGI
located in nuclear chromosome	IDA IDA: Inferred from direct assay	11555636	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12032866	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

high mobility group protein HMGI-C

high mobility group AT-hook protein 2

high mobility group protein I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06231	HMGA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17662	Hmga2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24123	Hmga2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hmga2	NCBI	NCBI:8091

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