Foxd1 - forkhead box D1 Gene

Mus musculus

Also known as BF-2; Hfh10; FREAC4; Hfhbf2

Gene ID: 15229 | Gene type: protein coding

About Foxd1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Acts upstream of or within axon guidance; branching involved in ureteric bud morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Orthologous to human FOXD1 (forkhead box D1). [provided by Alliance of Genome Resources, Apr 2022]

Foxd1 Products(1)

mRNA	Protein	Name
NM_008242.2	NP_032268.2	forkhead box protein D1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	13678594	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	13678594	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	13678594	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	13678594	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15509772	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	13678594	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	32868762	MGI
involved in dichotomous subdivision of terminal units involved in ureteric bud branching	IMP IMP: Inferred from mutant phenotype	15634693	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	8666231	MGI
involved in luteinizing hormone secretion	IMP IMP: Inferred from mutant phenotype	23284914	MGI
involved in metanephric capsule development	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in metanephric capsule specification	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in metanephric nephron development	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in nephrogenic mesenchyme development	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in pattern specification involved in metanephros development	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15634693	MGI
involved in positive regulation of kidney development	IMP IMP: Inferred from mutant phenotype	15634693	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	13678594	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	13678594	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein D1

FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4)	FREAC-4
HFH-BF-2	HNF-3/forkhead homolog, brain factor 2
brain factor 2	forkhead-related protein FKHL8
forkhead-related transcription factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05043	FOXD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19682	Foxd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26175	Foxd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxd1	NCBI	NCBI:2297

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