Foxf1 - forkhead box F1 Gene

Mus musculus

Also known as Hfh8; HFH-8; FREAC1; Foxf1a; Freac-1

Gene ID: 15227 | Gene type: protein coding

About Foxf1

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; respiratory system; and urethra. Used to study persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to human FOXF1 (forkhead box F1). [provided by Alliance of Genome Resources, Apr 2022]

Foxf1 Products(1)

mRNA	Protein	Name
NM_010426.3	NP_034556.2	forkhead box protein F1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15987774	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	7958446	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	11809759	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	11124112	MGI
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	9486531	MGI
acts upstream of or within cellular response to organic cyclic compound	IMP IMP: Inferred from mutant phenotype	18421012	MGI
acts upstream of or within detection of wounding	IMP IMP: Inferred from mutant phenotype	12500195	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within embryonic digestive tract development	IGI IGI: Inferred from genetic interaction	16439479	MGI
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within epithelial cell differentiation involved in mammary gland alveolus development	IGI IGI: Inferred from genetic interaction	16691571	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity	IGI IGI: Inferred from genetic interaction	16439479	MGI
acts upstream of or within extracellular matrix organization	IGI IGI: Inferred from genetic interaction	16439479	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	11124112	MGI
acts upstream of or within lateral mesodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	11124112	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	11437453	MGI
acts upstream of or within lung lobe morphogenesis	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within mesenchyme migration	IMP IMP: Inferred from mutant phenotype	17261592	MGI
acts upstream of or within mesoderm development	IGI IGI: Inferred from genetic interaction	11124112	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within mesodermal cell differentiation	IGI IGI: Inferred from genetic interaction	17881493	MGI
acts upstream of or within mesodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	17881493	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18421012	MGI
acts upstream of or within negative regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	18421012	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11124112	MGI
acts upstream of or within positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17261592	MGI
acts upstream of or within positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	17261592	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	11124112	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7958446	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17261592	MGI
acts upstream of or within right lung morphogenesis	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within smooth muscle cell differentiation	IGI IGI: Inferred from genetic interaction	17881493	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	11493558	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	11124112	MGI
acts upstream of or within trachea development	IMP IMP: Inferred from mutant phenotype	11493558	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	11124112	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	17261592	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein F1

HNF-3/forkhead homolog 8	forkhead box F1a
forkhead-related protein FKHL5	forkhead-related transcription factor 1
hepatocyte nuclear factor 3 forkhead homolog 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05049	FOXF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18387	Foxf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24868	Foxf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxf1	NCBI	NCBI:2294

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