Hand2 - heart and neural crest derivatives expressed 2 Gene

Mus musculus

Also known as Hed; Th2; dHAND; Ehand2; Thing2; bHLHa26

Gene ID: 15111 | Gene type: protein coding

About Hand2

Summary

Enables protein homodimerization activity and sequence-specific DNA binding activity. Contributes to E-box binding activity. Involved in several processes, including heart morphogenesis; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and nervous system development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hindlimb phalanx. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]

Hand2 Products(1)

mRNA	Protein	Name
NM_010402.4	NP_034532.3	heart- and neural crest derivatives-expressed protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11812799	MGI
contributes to E-box binding	IDA IDA: Inferred from direct assay	11812799	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	20144608	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11812799	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10924525	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11812799	MGI
enables sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	12070084	MGI
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	11812799	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	19144722	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult heart development	IMP IMP: Inferred from mutant phenotype	9171826	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	19341725	MGI
acts upstream of or within apoptotic process involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	11784028	MGI
involved in cardiac neural crest cell development involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19008477	MGI
acts upstream of or within cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	20144608	MGI
involved in cardiac right ventricle formation	IMP IMP: Inferred from mutant phenotype	11076755	MGI
acts upstream of or within cartilage morphogenesis	IGI IGI: Inferred from genetic interaction	17764670	MGI
acts upstream of or within cell proliferation involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	20144608	MGI
acts upstream of or within coronary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	21350214	MGI
acts upstream of or within determination of heart left/right asymmetry	IMP IMP: Inferred from mutant phenotype	9576835	MGI
acts upstream of or within embryonic digit morphogenesis	IDA IDA: Inferred from direct assay	12070084	MGI
involved in embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	19017795	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19341725	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	15576406	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	9171826	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	11784028	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9171826	MGI
acts upstream of or within mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19341725	MGI
acts upstream of or within mesenchyme development	IGI IGI: Inferred from genetic interaction	17764670	MGI
acts upstream of or within negative regulation of DNA binding	IDA IDA: Inferred from direct assay	19144722	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19144722	MGI
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19008477	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19341725	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	19144722	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19144722	MGI
acts upstream of or within neural crest cell development	IMP IMP: Inferred from mutant phenotype	9671575	MGI
acts upstream of positive effect norepinephrine biosynthetic process	IMP IMP: Inferred from mutant phenotype	19008477	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	17764670	MGI
acts upstream of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19144722	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19008477	MGI
acts upstream of or within peripheral nervous system neuron development	IDA IDA: Inferred from direct assay	16145670	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16145670	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	12070084	MGI
involved in positive regulation of semaphorin-plexin signaling pathway	IMP IMP: Inferred from mutant phenotype	19008477	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11812799	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20144608	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19008477	MGI
acts upstream of or within primary palate development	IMP IMP: Inferred from mutant phenotype	17531968	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15351717	MGI
involved in regulation of secondary heart field cardioblast proliferation	IMP IMP: Inferred from mutant phenotype	19008477	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	17531968	MGI
acts upstream of or within suckling behavior	IMP IMP: Inferred from mutant phenotype	17531968	MGI
acts upstream of or within sympathetic nervous system development	IDA IDA: Inferred from direct assay	16145670	MGI
involved in thymus development	IMP IMP: Inferred from mutant phenotype	19008477	MGI
acts upstream of or within tongue development	IMP IMP: Inferred from mutant phenotype	17531968	MGI
acts upstream of or within visceral serous pericardium development	IMP IMP: Inferred from mutant phenotype	21350214	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19144722	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	11812799	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heart- and neural crest derivatives-expressed protein 2

deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2	heart and neural crest derivatives expressed transcript 2
helix-loop-helix transcription factor expressed in embryo and deciduum	thing-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05997	HAND2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174480	Mouse Hand2 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hand2	NCBI	NCBI:9464

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