2. Gene
  3. Adgrg1 - adhesion G protein-coupled receptor G1 Gene

Adgrg1 - adhesion G protein-coupled receptor G1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cyt28; Gpr56; TM7LN4; TM7XN1

Gene ID: 14766 | Gene type: protein coding

About Adgrg1

Summary

Enables several functions, including Collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Involved in several processes, including negative regulation of neuron migration; positive regulation of Rho protein signal transduction; and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Apr 2022]

Adgrg1 Products(25)

mRNA Protein Name
NM_001198894.2 NP_001185823.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403764.1 NP_001390693.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403765.1 NP_001390694.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403766.1 NP_001390695.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403767.1 NP_001390696.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403768.1 NP_001390697.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403769.1 NP_001390698.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403770.1 NP_001390699.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403771.1 NP_001390700.1 adhesion G-protein coupled receptor G1 isoform a precursor
NM_001403772.1 NP_001390701.1 adhesion G-protein coupled receptor G1 isoform b precursor
NM_001403776.1 NP_001390705.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403778.1 NP_001390707.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403779.1 NP_001390708.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403780.1 NP_001390709.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403781.1 NP_001390710.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403782.1 NP_001390711.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403783.1 NP_001390712.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403784.1 NP_001390713.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403785.1 NP_001390714.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403786.1 NP_001390715.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403787.1 NP_001390716.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403788.1 NP_001390717.1 adhesion G-protein coupled receptor G1 isoform c precursor
NM_001403789.1 NP_001390718.1 adhesion G-protein coupled receptor G1 isoform d precursor
NM_001403790.1 NP_001390719.1 adhesion G-protein coupled receptor G1 isoform d precursor
NM_018882.4 NP_061370.2 adhesion G-protein coupled receptor G1 isoform c precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
21768377 MGI
enables collagen binding IDA
IDA: Inferred from direct assay
21768377 MGI
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18509043 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
27068534 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
36453010 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cerebral cortex radial glia-guided migration IMP
IMP: Inferred from mutant phenotype
18509043 MGI
acts upstream of or within cerebral cortex regionalization IMP
IMP: Inferred from mutant phenotype
24531968 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
26880577 MGI
involved in layer formation in cerebral cortex IMP
IMP: Inferred from mutant phenotype
18509043 MGI
involved in negative regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
18509043 MGI
acts upstream of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
24531968 MGI
involved in positive regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
21768377 MGI
acts upstream of or within positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
24531968 MGI
involved in seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
20981830 MGI
Cellular Component GO Annotation Evidence Reference Source
located in glial limiting end-foot IDA
IDA: Inferred from direct assay
18509043 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adhesion G-protein coupled receptor G1

G-protein coupled receptor 56

secretin receptor

serpentine receptor cyt28

Adgrg1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Adgrg1 Q8K209 Adgrl1 Mus musculus Q80TR1
Anti Bait CoIP
36453010
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00354 ADGRG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20135 Adgrg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26638 Adgrg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adgrg1 NCBI NCBI:9289