Lrp2 - low density lipoprotein receptor-related protein 2 Gene

Mus musculus

Also known as Gp330; Megalin; b2b1625.2Clo; D230004K18Rik

Gene ID: 14725 | Gene type: protein coding

About Lrp2

Summary

Predicted to enable several functions, including PDZ domain binding activity; chaperone binding activity; and insulin-like growth factor I binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including animal organ development; circulatory system development; and vitamin metabolic process. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; heart and pericardium; metanephros; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrp2 Products(1)

mRNA	Protein	Name
NM_001081088.2	NP_001074557.1	low-density lipoprotein receptor-related protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10772929	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	15623804	MGI
involved in coronary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	26822476	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within cranial skeletal system development	IMP IMP: Inferred from mutant phenotype	34463328	MGI
acts upstream of or within diol metabolic process	IMP IMP: Inferred from mutant phenotype	10052453	MGI
involved in folate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	24639464	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15623804	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	34463328	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	27002738	MGI
involved in male gonad development	IMP IMP: Inferred from mutant phenotype	16143106	MGI
involved in negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20460439	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	24639464	MGI
involved in neuron projection arborization	IMP IMP: Inferred from mutant phenotype	20637285	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	34463328	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	26822476	MGI
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	20460439	MGI
involved in positive regulation of oligodendrocyte progenitor proliferation	IMP IMP: Inferred from mutant phenotype	22354480	MGI
involved in protein transport	IDA IDA: Inferred from direct assay	17324488	MGI
involved in pulmonary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	26822476	MGI
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	15623804	MGI
acts upstream of or within receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	10052453	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	12724130	MGI
involved in response to leptin	IDA IDA: Inferred from direct assay	17324488	MGI
involved in secondary heart field specification	IMP IMP: Inferred from mutant phenotype	26822476	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	17846082	MGI
involved in vagina development	IMP IMP: Inferred from mutant phenotype	16143106	MGI
involved in ventricular compact myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	26822476	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within vitamin D metabolic process	IMP IMP: Inferred from mutant phenotype	10052453	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15616221	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	15342463	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15616221	MGI
located in axon	IDA IDA: Inferred from direct assay	20637285	MGI
located in brush border	IDA IDA: Inferred from direct assay	12815097	MGI
located in brush border membrane	IDA IDA: Inferred from direct assay	10662735	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	15616221	MGI
located in dendrite	IDA IDA: Inferred from direct assay	20637285	MGI
located in endocytic vesicle	IDA IDA: Inferred from direct assay	15616221	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15616221	MGI
located in endosome	IDA IDA: Inferred from direct assay	10766831	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16143106	MGI
located in membrane	IDA IDA: Inferred from direct assay	15082773	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16901941	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low-density lipoprotein receptor-related protein 2

glycoprotein 330

Lrp2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86698	LRP2 Antibody (YA6390)	IHC-P, WB, IF-Tissue, IHC-F, ICC/IF	Mouse, Rat, Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00727	ANKRD37 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07797	LRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13536	SNX25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17962	Lrp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24433	Lrp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp2	NCBI	NCBI:4036

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