Got1 - glutamic-oxaloacetic transaminase 1, soluble Gene

Mus musculus

Also known as cCAT; Got-1; cAspAT

Gene ID: 14718 | Gene type: protein coding

About Got1

Summary

Enables L-aspartate:2-oxoglutarate aminotransferase activity and phosphatidylserine decarboxylase activity. Acts upstream of or within several processes, including dicarboxylic acid metabolic process; fatty acid homeostasis; and glycerol biosynthetic process. Located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Got1 Products(1)

mRNA	Protein	Name
NM_010324.2	NP_034454.2	aspartate aminotransferase, cytoplasmic

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA IDA: Inferred from direct assay	1914521	MGI
enables phosphatidylserine decarboxylase activity	IDA IDA: Inferred from direct assay	3242498	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within aspartate biosynthetic process	IDA IDA: Inferred from direct assay	4193185	MGI
acts upstream of or within fatty acid homeostasis	IDA IDA: Inferred from direct assay	17545671	MGI
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	17545671	MGI
acts upstream of or within glutamate catabolic process to aspartate	IDA IDA: Inferred from direct assay	4193185	MGI
acts upstream of or within glycerol biosynthetic process	IDA IDA: Inferred from direct assay	17545671	MGI
involved in malate-aspartate shuttle	IMP IMP: Inferred from mutant phenotype	37813964	MGI
acts upstream of or within oxaloacetate metabolic process	IDA IDA: Inferred from direct assay	4193185	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	4193185	MGI
located in cytosol	IDA IDA: Inferred from direct assay	4193185	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aspartate aminotransferase, cytoplasmic

cysteine aminotransferase, cytoplasmic	cysteine transaminase, cytoplasmic
cytosolic aspartate aminotransferase	glutamate oxaloacetate transaminase 1, soluble
transaminase A

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0091	Adapalene	99.98%	Yes
HY-B0091R	Adapalene (Standard)	/	Unkown
HY-B0091A	Adapalene sodium salt	/	Unkown

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122723	GOT1 inhibitor-1	Inhibitor	99.45%	Unkown
HY-160818	MC3138	Activator	99.27%	Unkown
HY-124825	iGOT1-01		99.77%	Unkown
HY-N6237	Aspulvinone O		≥96.0%	Unkown
HY-RS05605	GOT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B0091S	Adapalene-d3		/	Unkown
HY-RS05596	GOLT1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16967	Got1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23410	Got1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Got1	NCBI	NCBI:2805

Name
Email *

	Sorry, but the email address you supplied was invalid.