SLFN13 - schlafen family member 13 Gene

Homo sapiens

Also known as SLFN10; hSLFN13

Gene ID: 146857 | Gene type: protein coding

About SLFN13

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,435,096-35,449,766 (from NCBI)

This gene has 11 transcripts (splice variants), 110 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 5.2), spleen (RPKM 4.2) and 24 other tissues.

Summary

Enables endoribonuclease activity. Involved in rRNA catabolic process and tRNA catabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SLFN13 Products(1)

mRNA	Protein	Name
NM_144682.6	NP_653283.3	schlafen family member 13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	29563550	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in rRNA catabolic process	IDA IDA: Inferred from direct assay	29563550	GOA
involved in tRNA decay	IDA IDA: Inferred from direct assay	29563550	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	29563550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLFN13 Protein Structure

AlbA_2

DUF2075

0
200
400
600
800
897 a.a.

Protein Preferred Names

Protein Names

schlafen family member 13

schlafen-13

Related Diseases

Diseases

Alias

Bleeding Disorder, Platelet-Type, 20

Platelet-Type Bleeding Disorder 20	BDPLT20
Autosomal Dominant Thrombocytopenia With Platelet Secretion Defect

Monkeypox

Monkeypox Virus Infections

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13366	SLFN13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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