Gm2a - GM2 ganglioside activator protein Gene

Mus musculus

Also known as SAP-3; GM2-AP

Gene ID: 14667 | Gene type: protein coding

About Gm2a

Summary

Enables beta-N-acetylhexosaminidase activity and enzyme activator activity. Acts upstream of or within several processes, including ganglioside catabolic process; lipid storage; and neuromuscular process controlling balance. Located in mitochondrion. Is expressed in several structures, including back skin; central nervous system; genitourinary system; hemolymphoid system; and retina. Used to study GM2 gangliosidosis, AB variant. Human ortholog(s) of this gene implicated in GM2 gangliosidosis and GM2 gangliosidosis, AB variant. Orthologous to human GM2A (GM2 ganglioside activator). [provided by Alliance of Genome Resources, Apr 2022]

Gm2a Products(1)

mRNA	Protein	Name
NM_010299.3	NP_034429.1	ganglioside GM2 activator precursor

Protein Preferred Names

Protein Names

ganglioside GM2 activator

cerebroside sulfate activator protein	shingolipid activator protein 3
sphingolipid activator protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05513	GM2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18134	Gm2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24609	Gm2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gm2a	NCBI	NCBI:2760

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