Gclm - glutamate-cysteine ligase, modifier subunit Gene

Mus musculus

Also known as Gcmc; Glclr

Gene ID: 14630 | Gene type: protein coding

About Gclm

Summary

Enables glutamate-cysteine Ligase catalytic subunit binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and positive regulation of glutamate-cysteine Ligase activity. Part of glutamate-cysteine Ligase complex. Is expressed in several structures, including alimentary system; liver; nervous system; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine Ligase modifier subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclm Products(1)

mRNA	Protein	Name
NM_008129.4	NP_032155.1	glutamate--cysteine ligase regulatory subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutamate-cysteine ligase catalytic subunit binding	IDA IDA: Inferred from direct assay	12384496	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12384496	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic mitochondrial changes	IGI IGI: Inferred from genetic interaction	15288121	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within cysteine metabolic process	IMP IMP: Inferred from mutant phenotype	12384496	MGI
acts upstream of or within glutathione biosynthetic process	IDA IDA: Inferred from direct assay	16081425	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	12384496	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	15288121	MGI
acts upstream of or within positive regulation of glutamate-cysteine ligase activity	IDA IDA: Inferred from direct assay	12384496	MGI
acts upstream of or within regulation of mitochondrial depolarization	IGI IGI: Inferred from genetic interaction	15288121	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	12384496	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of glutamate-cysteine ligase complex	IDA IDA: Inferred from direct assay	12384496	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate--cysteine ligase regulatory subunit

GCS light chain	gamma-ECS regulatory subunit
gamma-glutamylcysteine synthetase regulatory subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015600	2-Acetamidophenol		99.61%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-121523	MIND4-17	Activator	99.93%	Unkown
HY-172598	Keap1-Nrf2-IN-28	Inhibitor	/	Unkown
HY-RS05334	GCLM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18936	Gclm Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25426	Gclm Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gclm	NCBI	NCBI:2730

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