1. Gene
  2. Gdf5 - growth differentiation factor 5 Gene

Gdf5 - growth differentiation factor 5 Gene

Mus musculus

Also known as bp; brp; BMP-14; Cdmp-1

Gene ID: 14563 | Gene type: protein coding

About Gdf5

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation. [provided by RefSeq, Aug 2016]

Gdf5 Products(1)

mRNA Protein Name
NM_008109.4 NP_032135.2 growth/differentiation factor 5 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14660436 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth/differentiation factor 5

bone morphogenetic protein 14

cartilage-derived morphogenetic protein-1

Orthologs Information

Species Symbol Source ID
Homo sapiens Gdf5 NCBI NCBI:8200