2. Gene
  3. Gch1 - GTP cyclohydrolase 1 Gene

Gch1 - GTP cyclohydrolase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gch; GTPCH; GTP-CH; GTP-CH-I

Gene ID: 14528 | Gene type: protein coding

About Gch1

Summary

Enables GTP cyclohydrolase I activity. Involved in positive regulation of heart rate. Acts upstream of or within regulation of lung blood pressure. Predicted to be located in cytoplasmic vesicle; cytosol; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study BH4-deficient hyperphenylalaninemia B. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia B; bipolar disorder; dystonia; and dystonia 5. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Gch1 Products(1)

mRNA Protein Name
NM_008102.4 NP_032128.1 GTP cyclohydrolase 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables GTP cyclohydrolase I activity IDA
IDA: Inferred from direct assay
7524491 MGI
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
25557619 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
15824199 MGI
acts upstream of or within regulation of lung blood pressure IMP
IMP: Inferred from mutant phenotype
15824199 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTP cyclohydrolase 1

GTP cyclohydrolase I

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05327 GCH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18133 Gch1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24608 Gch1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gch1 NCBI NCBI:2643