Gcg - glucagon Gene

Mus musculus

Also known as Glu; PPG; GLP-1

Gene ID: 14526 | Gene type: protein coding

About Gcg

Summary

This gene encodes glucagon, a pancreatic hormone that counteracts the action of Insulin in the bloodstream. The encoded protein is processed to generate glucagon and two Other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of Insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing Apoptosis. [provided by RefSeq, Apr 2015]

Gcg Products(1)

mRNA	Protein	Name
NM_008100.4	NP_032126.1	pro-glucagon preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables receptor ligand activity	IDA IDA: Inferred from direct assay	30380405	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19915011	MGI
involved in cellular response to glucagon stimulus	IDA IDA: Inferred from direct assay	30380405	MGI
acts upstream of gluconeogenesis	IDA IDA: Inferred from direct assay	24051374	MGI
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	22037645	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19915011	MGI
acts upstream of or within negative regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	19915011	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19915011	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19915011	MGI
involved in positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	19915011	MGI
acts upstream of or within positive regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	24051374	MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	19915011	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19915011	MGI
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	19915011	MGI
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	19915011	MGI
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	19915011	MGI
involved in protein kinase A signaling	IMP IMP: Inferred from mutant phenotype	19915011	MGI
acts upstream of or within regulation of insulin secretion	IDA IDA: Inferred from direct assay	14736883	MGI
involved in regulation of insulin secretion	IDA IDA: Inferred from direct assay	22037645	MGI
involved in response to activity	IDA IDA: Inferred from direct assay	22037645	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17928203	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	17693256	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	30380405	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pro-glucagon

glucagon-like peptide I

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109528	Fomivirsen sodium	Inhibitor	≥99.0%	Unkown
HY-109556	Insulin Detemir	Activator	≥95.0%	Unkown
HY-118874	Oblimersen		/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132596	Tivanisiran	Inhibitor	92.62%	Phase 3
HY-148100	Emapticap pegol	Inhibitor	/	Phase 2
HY-P10031A	SAR441255 TFA	Agonist	99.65%	Phase 1
HY-P10031	SAR441255	Agonist	99.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150738	ODN 2088	Antagonist	93.63%	Unkown
HY-150217	CpG ODN 10101		94.06%	Unkown
HY-150736	ODN 20844	Inhibitor	92.60%	Unkown
HY-150748	ODN D-SL01	Agonist	99.94%	Unkown
HY-148412	Monarsen	Inhibitor	/	Unkown
HY-150213	ODN BW001	Inhibitor	/	Unkown
HY-P5074	GRPP (human)	Agonist	/	Unkown
HY-RS05323	GCG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17156	Gcg Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23606	Gcg Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gcg	NCBI	NCBI:2641

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