Fosl2 - fos-like antigen 2 Gene

Mus musculus

Also known as Fra-2

Gene ID: 14284 | Gene type: protein coding

About Fosl2

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within keratinocyte development; positive regulation of fibroblast proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; skeleton; skin; and telencephalon. Used to study idiopathic pulmonary fibrosis and systemic scleroderma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fosl2 Products(1)

mRNA	Protein	Name
NM_008037.4	NP_032063.2	fos-related antigen 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24464219	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19289495	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	25547114	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	22326952	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	28566276	MGI
acts upstream of or within B cell proliferation	IMP IMP: Inferred from mutant phenotype	28566276	MGI
acts upstream of or within NK T cell differentiation	IMP IMP: Inferred from mutant phenotype	19620306	MGI
acts upstream of or within T cell differentiation	IDA IDA: Inferred from direct assay	32610127	MGI
acts upstream of or within T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	32610127	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	32610127	MGI
acts upstream of or within T-helper 2 cell cytokine production	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within alveolar secondary septum development	IMP IMP: Inferred from mutant phenotype	28818870	MGI
acts upstream of or within bone development	IDA IDA: Inferred from direct assay	24046454	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	24046454	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	15509771	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	15509771	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	18548006	MGI
acts upstream of or within chemokine (C-C motif) ligand 11 production	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within chemokine production	IDA IDA: Inferred from direct assay	33655757	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15509771	MGI
acts upstream of or within chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	15509771	MGI
acts upstream of or within collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	20837772	MGI
acts upstream of or within collagen metabolic process	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within cytokine production	IDA IDA: Inferred from direct assay	33655757	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	30181393	MGI
acts upstream of or within fat cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24464219	MGI
acts upstream of or within fat cell differentiation	IMP IMP: Inferred from mutant phenotype	24464219	MGI
acts upstream of or within fat pad development	IMP IMP: Inferred from mutant phenotype	24464219	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	22326952	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18548006	MGI
acts upstream of or within glucose homeostasis	IDA IDA: Inferred from direct assay	24046454	MGI
acts upstream of or within granulocyte macrophage colony-stimulating factor production	IMP IMP: Inferred from mutant phenotype	30181393	MGI
acts upstream of or within growth plate cartilage development	IMP IMP: Inferred from mutant phenotype	15509771	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	19620306	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IDA IDA: Inferred from direct assay	33655757	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	24464219	MGI
acts upstream of or within inflammatory response	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	32610127	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	19620306	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	30181393	MGI
acts upstream of or within insulin metabolic process	IDA IDA: Inferred from direct assay	24046454	MGI
acts upstream of or within interleukin-2 production	IMP IMP: Inferred from mutant phenotype	19620306	MGI
acts upstream of or within interleukin-4 production	IMP IMP: Inferred from mutant phenotype	19620306	MGI
acts upstream of or within keratinocyte development	IMP IMP: Inferred from mutant phenotype	25547114	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	28818870	MGI
acts upstream of or within lung connective tissue development	IMP IMP: Inferred from mutant phenotype	31135379	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	30181393	MGI
acts upstream of or within macrophage differentiation	IDA IDA: Inferred from direct assay	31135379	MGI
acts upstream of or within macrophage differentiation	IMP IMP: Inferred from mutant phenotype	30181393	MGI
acts upstream of or within mucus secretion	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	15509771	MGI
acts upstream of or within myofibroblast differentiation	IMP IMP: Inferred from mutant phenotype	28818870	MGI
acts upstream of or within neutrophil differentiation	IMP IMP: Inferred from mutant phenotype	30181393	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	20837772	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20837772	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	18548006	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22585681	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	7936655	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25547114	MGI
acts upstream of or within regulation of multicellular organism growth	IDA IDA: Inferred from direct assay	24046454	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	24046454	MGI
acts upstream of or within regulation of myofibroblast differentiation	IDA IDA: Inferred from direct assay	31135379	MGI
acts upstream of or within regulation of myofibroblast differentiation	IMP IMP: Inferred from mutant phenotype	31135379	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	28566276	MGI
acts upstream of or within response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	33655757	MGI
acts upstream of or within response to bleomycin	IDA IDA: Inferred from direct assay	31135379	MGI
acts upstream of or within response to glucocorticoid	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	18548006	MGI
acts upstream of or within response to interleukin-13	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within response to interleukin-7	IMP IMP: Inferred from mutant phenotype	28566276	MGI
acts upstream of or within response to leukemia inhibitory factor	IMP IMP: Inferred from mutant phenotype	18548006	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	30181393	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within smooth muscle tissue development	IDA IDA: Inferred from direct assay	30233597	MGI
acts upstream of or within tissue remodeling	IDA IDA: Inferred from direct assay	30233597	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	25547114	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fos-related antigen 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05035	FOSL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18065	Fosl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24540	Fosl2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fosl2	NCBI	NCBI:2355

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