Fos - FBJ osteosarcoma oncogene Gene

Mus musculus

Also known as cFos; c-fos; D12Rfj1

Gene ID: 14281 | Gene type: protein coding

About Fos

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including positive regulation of osteoclast differentiation; response to muscle stretch; and skeletal muscle cell differentiation. Located in endoplasmic reticulum and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fos Products(1)

mRNA	Protein	Name
NM_010234.3	NP_034364.1	protein c-Fos

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12486129	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11925568	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11925568	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12220541	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	11925568	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11925568	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20442316	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	2138707	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	19365557	MGI
acts upstream of or within cellular response to stimulus	IMP IMP: Inferred from mutant phenotype	9294610	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	11925568	MGI
acts upstream of osteoclast differentiation	IDA IDA: Inferred from direct assay	23395171	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	23395171	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9294610	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11925568	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12220541	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11925568	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22284419	MGI
acts upstream of or within response to muscle stretch	IDA IDA: Inferred from direct assay	20442316	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	9098922	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9294610	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26475860	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	26475860	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7595148	MGI
part of transcription factor AP-1 complex	IPI IPI: Inferred from physical interaction	1631061	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12943993	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein c-Fos

cellular oncogene fos	proto-oncogene c-Fos
proto-oncogene protein c-fos	transcription factor AP-1 subunit c-Fos

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113756A	Latanoprost acid	Inhibitor	99.62%	Unkown
HY-A0116A	Trandolaprilate hydrate	Inhibitor	97.30%	Unkown
HY-A0116	Trandolaprilate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12270	T-5224	Inhibitor	99.59%	Phase 2
HY-100426A	Osemozotan hydrochloride	Agonist	/	Phase 2
HY-113726	Nerisopam	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10408	Candidalysin	Activator	99.38%	Unkown
HY-N2119	Sciadopitysin	Inhibitor	≥99.0%	Unkown
HY-N0231	Bavachalcone		99.95%	Unkown
HY-113438	15(S)-HPETE		97.3%	Unkown
HY-N6837	Fructo-oligosaccharide DP7/GF6		99.94%	Unkown
HY-107621	U0124		≥98.0%	Unkown
HY-N6836	Fructo-oligosaccharide DP8/GF7		99.76%	Unkown
HY-P10506	CMX-8933	Activator	99.82%	Unkown
HY-169021	JNK-1-IN-3	Inhibitor	98.44%	Unkown
HY-100839	(RS)-(Tetrazol-5-yl)glycine	Agonist	96.53%	Unkown
HY-114753	Neboglamine	Modulator	/	Unkown
HY-113443	12(S)-HPETE	Activator	/	Unkown
HY-120306	HHL-6	Inhibitor	/	Unkown
HY-131721	14,15-EET-SI	Activator	/	Unkown
HY-15026	ATB 429		/	Unkown
HY-168482	NF-κB/MAPK-IN-2	Inhibitor	/	Unkown
HY-168895	c-Fos-IN-1		/	Unkown
HY-169451	Cannabidiolic acid methyl ester	Modulator	/	Unkown
HY-176019	Methylcarbamyl PAF C-8		/	Unkown
HY-A0116S1	Trandolaprilate-d6		/	Unkown
HY-N11775	Eudebeiolide B		/	Unkown
HY-N3071	Picrasidine I		/	Unkown
HY-N6834	Fructo-oligosaccharide DP10/GF9		≥98.0%	Unkown
HY-N6835	Fructo-oligosaccharide DP9/GF8		99.83%	Unkown
HY-N7008	Fructo-oligosaccharide DP11/GF10		/	Unkown
HY-N7009	Fructo-oligosaccharide DP12/GF11		/	Unkown
HY-P10927	BRP	Activator	/	Unkown
HY-RS05032	FOS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16815	Fos Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23255	Fos Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fos	NCBI	NCBI:2353

Name
Email *

	Sorry, but the email address you supplied was invalid.