Fadd - Fas (TNFRSF6)-associated via death domain Gene

Mus musculus

Also known as Mort1/FADD

Gene ID: 14082 | Gene type: protein coding

About Fadd

Summary

Predicted to enable several functions, including Caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]

Fadd Products(1)

mRNA	Protein	Name
NM_010175.6	NP_034305.1	FAS-associated death domain protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12884866	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	8565075	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	21876153	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10588860	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16183742	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	13679421	MGI
involved in lymph node development	IGI IGI: Inferred from genetic interaction	21876153	MGI
acts upstream of or within motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	13679421	MGI
involved in negative regulation of activation-induced cell death of T cells	IMP IMP: Inferred from mutant phenotype	21876153	MGI
acts upstream of or within negative regulation of necroptotic process	IGI IGI: Inferred from genetic interaction	22089168	MGI
involved in positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in positive regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in positive regulation of adaptive immune response	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in positive regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	8565075	MGI
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	12887920	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	22675671	MGI
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	21876153	MGI
involved in spleen development	IGI IGI: Inferred from genetic interaction	21876153	MGI
involved in thymus development	IGI IGI: Inferred from genetic interaction	21876153	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

FAS-associated death domain protein

FAS-associating death domain-containing protein	Fas-associating protein with death domain
mediator of receptor induced toxicity	protein FADD

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14622	Necrostatin 2	Inhibitor	99.92%	Unkown
HY-109582	ADT-OH		98.55%	Unkown
HY-132203	Necrostatin-34	Inhibitor	98.90%	Unkown
HY-148454	Necroptosis-IN-3	Inhibitor	99.77%	Unkown
HY-119369	FadD32 Inhibitor-1	Inhibitor	/	Unkown
HY-RS04665	FADD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-168770	Cl-Necrostatin-1	Inhibitor	/	Unkown
HY-RS17138	Fadd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23584	Fadd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fadd	NCBI	NCBI:8772

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