Emp2 - epithelial membrane protein 2 Gene

Mus musculus

Also known as XMP

Gene ID: 13731 | Gene type: protein coding

About Emp2

Summary

Enables Integrin binding activity. Involved in several processes, including early endosome to late endosome transport; embryo implantation; and membrane raft assembly. Acts upstream of or within positive regulation of integrin-mediated signaling pathway. Located in Golgi apparatus; apical plasma membrane; and cell surface. Colocalizes with cytoplasmic vesicle; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; medulla oblongata lateral wall; naris epithelium; respiratory system; and ventricular layer. Used to study placental insufficiency. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Emp2 Products(1)

mRNA	Protein	Name
NM_007929.2	NP_031955.2	epithelial membrane protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	12189152	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	12763482	MGI
NOT involved in caveola assembly	IDA IDA: Inferred from direct assay	14978215	MGI
involved in early endosome to late endosome transport	IDA IDA: Inferred from direct assay	18400107	MGI
involved in embryo implantation	IMP IMP: Inferred from mutant phenotype	16487956	MGI
involved in embryonic process involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	28295343	MGI
involved in heart formation	IMP IMP: Inferred from mutant phenotype	30773261	MGI
involved in membrane raft assembly	IDA IDA: Inferred from direct assay	14978215	MGI
involved in natural killer cell proliferation	IMP IMP: Inferred from mutant phenotype	28295343	MGI
involved in neutrophil migration	IMP IMP: Inferred from mutant phenotype	31550239	MGI
involved in plasma membrane raft assembly	IMP IMP: Inferred from mutant phenotype	31550239	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	28295343	MGI
involved in positive regulation of cardiac epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	30773261	MGI
acts upstream of or within positive regulation of integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16216233	MGI
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	31550239	MGI
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	12189152	MGI
involved in regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	12189152	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12189152	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	16487956	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16216233	MGI
NOT colocalizes with caveola	IDA IDA: Inferred from direct assay	14978215	MGI
located in cell surface	IDA IDA: Inferred from direct assay	16487956	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16216233	MGI
colocalizes with cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12189152	MGI
colocalizes with membrane raft	IDA IDA: Inferred from direct assay	12763482	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	14978215	MGI
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	12189152	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

epithelial membrane protein 2

EMP-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04360	EMP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18355	Emp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24834	Emp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Emp2	NCBI	NCBI:2013

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