2. Gene
  3. Eln - elastin Gene

Eln - elastin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as E030024M20Rik

Gene ID: 13717 | Gene type: protein coding

About Eln

Summary

This gene encodes elastin, the extracellular matrix protein that forms a major structural component of several tissues including lungs and arterial walls. Cleavage of the signal peptide from the encoded precursor generates soluble tropoelastin which undergoes lysine-derived crosslinking to form elastin Polymers. Mice lacking the encoded protein exhibit defective lung development, and die of an obstructive arterial disease resulting from subendothelial cell proliferation and reorganization of smooth muscle. [provided by RefSeq, Aug 2015]

Eln Products(2)

mRNA Protein Name
NM_007925.4 NP_031951.2 elastin precursor
NM_007925.4 NP_031951.2 elastin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables extracellular matrix constituent conferring elasticity IDA
IDA: Inferred from direct assay
20576933 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16251195 MGI
Biological Process GO Annotation Evidence Reference Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
20576933 MGI
involved in extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
20576933 MGI
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
14614988 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
14614988 MGI
acts upstream of or within stress fiber assembly IMP
IMP: Inferred from mutant phenotype
14614988 MGI
Cellular Component GO Annotation Evidence Reference Source
located in elastic fiber IDA
IDA: Inferred from direct assay
17099216 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

elastin

tropoelastin

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15043 ELN-441958 Antagonist 99.51% Unkown
HY-115038 ELN484228 Antagonist 99.50% Unkown
HY-50882 ELN318463 Inhibitor 99.45% Unkown
HY-RS04316 ELN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-50882A ELN318463 racemate Inhibitor / Unkown
HY-RS20236 Eln Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26743 Eln Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eln NCBI NCBI:2006