2. Gene
  3. Dnm2 - dynamin 2 Gene

Dnm2 - dynamin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dyn2; Udnm; b2b2159Clo

Gene ID: 13430 | Gene type: protein coding

About Dnm2

Summary

Predicted to enable several functions, including D2 Dopamine Receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Located in clathrin-coated pit and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; skin; and white fat. Used to study centronuclear myopathy; cystic kidney disease; and myopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (Dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]

Dnm2 Products(7)

mRNA Protein Name
NM_001039520.2 NP_001034609.1 dynamin-2 isoform 2
NM_001253893.1 NP_001240822.1 dynamin-2 isoform 1
NM_001253894.1 NP_001240823.1 dynamin-2 isoform 4
NM_001357718.1 NP_001344647.1 dynamin-2 isoform 5
NM_001357719.1 NP_001344648.1 dynamin-2 isoform 6
NM_001357721.1 NP_001344650.1 dynamin-2 isoform 7
NM_007871.2 NP_031897.2 dynamin-2 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11018064 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
21689597 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
21689597 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence Reference Source
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
26437238 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
23746204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynamin-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132583 IONIS-DNM2-2.5Rx Inhibitor / Unkown
HY-132583A IONIS-DNM2-2.5Rx sodium Inhibitor / Unkown
HY-RS03905 DNM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22143 Dnm2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnm2 NCBI NCBI:1785