Ctsh - cathepsin H Gene

About Ctsh

Summary

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin-h.html" target="_blank" style="color: #6a4b92; font-weight:bold;">cathepsin H mini, heavy, and light chains. In rat and human, these three chains can associate to form the mature enzyme, which has both Aminopeptidase.html" target="_blank" style="color: #6a4b92; font-weight:bold;">aminopeptidase and endopeptidase activities. Homozygous knockout mice for this gene exhibit impaired lung surfactant processing and reduced tumorigenesis in a pancreatic Cancer.html" target="_blank" style="color: #6a4b92; font-weight:bold;">cancer model. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]