2. Gene
  3. Ctbp2 - C-terminal binding protein 2 Gene

Ctbp2 - C-terminal binding protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ribeye; Gtrgeo6; D7Ertd45e

Gene ID: 13017 | Gene type: protein coding

About Ctbp2

Summary

Enables several functions, including retinoic acid receptor binding activity; transcription coactivator activity; and transcription corepressor activity. A structural constituent of presynaptic active zone. Involved in negative regulation of transcription, DNA-templated; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of chromatin binding activity; and positive regulation of retinoic acid receptor signaling pathway. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Part of transcription repressor complex. Is active in presynaptic active zone cytoplasmic component and presynaptic cytosol. Is expressed in several structures, including alimentary system; limb; lung; nervous system; and retina layer. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ctbp2 Products(19)

mRNA Protein Name
NM_001170744.2 NP_001164215.1 C-terminal-binding protein 2 isoform 1
NM_001347623.2 NP_001334552.1 C-terminal-binding protein 2 isoform 3
NM_001412294.1 NP_001399223.1 C-terminal-binding protein 2 isoform 4
NM_001412295.1 NP_001399224.1 C-terminal-binding protein 2 isoform 2
NM_001412296.1 NP_001399225.1 C-terminal-binding protein 2 isoform 2
NM_001412297.1 NP_001399226.1 C-terminal-binding protein 2 isoform 2
NM_001412298.1 NP_001399227.1 C-terminal-binding protein 2 isoform 2
NM_001412299.1 NP_001399228.1 C-terminal-binding protein 2 isoform 2
NM_001412300.1 NP_001399229.1 C-terminal-binding protein 2 isoform 2
NM_001412301.1 NP_001399230.1 C-terminal-binding protein 2 isoform 2
NM_001412302.1 NP_001399231.1 C-terminal-binding protein 2 isoform 2
NM_001412303.1 NP_001399232.1 C-terminal-binding protein 2 isoform 3
NM_001412304.1 NP_001399233.1 C-terminal-binding protein 2 isoform 3
NM_001412305.1 NP_001399234.1 C-terminal-binding protein 2 isoform 3
NM_001412306.1 NP_001399235.1 C-terminal-binding protein 2 isoform 3
NM_001412307.1 NP_001399236.1 C-terminal-binding protein 2 isoform 3
NM_001412308.1 NP_001399237.1 C-terminal-binding protein 2 isoform 3
NM_001412309.1 NP_001399238.1 C-terminal-binding protein 2 isoform 3
NM_009980.5 NP_034110.1 C-terminal-binding protein 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
23775127 MGI
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
23775127 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11328817 MGI
enables structural constituent of presynaptic active zone IDA
IDA: Inferred from direct assay
26929012 MGI
enables structural constituent of presynaptic active zone IMP
IMP: Inferred from mutant phenotype
26929012 MGI
enables transcription coactivator activity IGI
IGI: Inferred from genetic interaction
23775127 MGI
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
10438528 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
10567582 MGI
enables transcription corepressor activity IPI
IPI: Inferred from physical interaction
12444977 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18483224 MGI
acts upstream of or within negative regulation of DNA-templated transcription IPI
IPI: Inferred from physical interaction
12444977 MGI
acts upstream of or within positive regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
23775127 MGI
acts upstream of or within positive regulation of retinoic acid receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23775127 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
23775127 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23775127 MGI
involved in synaptic vesicle docking IDA
IDA: Inferred from direct assay
26929012 MGI
involved in synaptic vesicle docking IMP
IMP: Inferred from mutant phenotype
26929012 MGI
involved in white fat cell differentiation IDA
IDA: Inferred from direct assay
18483224 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
22745816 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15728193 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
26929012 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16702210 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
15728193 MGI
is active in photoreceptor ribbon synapse IMP
IMP: Inferred from mutant phenotype
26929012 MGI
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
15728193 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
22745816 MGI
located in ribbon synapse IDA
IDA: Inferred from direct assay
19932743 MGI
located in synapse IDA
IDA: Inferred from direct assay
20368623 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
18483224 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-terminal-binding protein 2

gene trap ROSA b-geo 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135046 MTOB sodium Inhibitor 98.24% Unkown
HY-RS03284 CTBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20897 Ctbp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27414 Ctbp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctbp2 NCBI NCBI:1488