2. Gene
  3. Cs - citrate synthase Gene

Cs - citrate synthase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cis; Ahl4; 2610511A05Rik; 9030605P22Rik

Gene ID: 12974 | Gene type: protein coding

About Cs

Summary

The protein encoded by this gene is a central metabolic pathway enzyme, catalyzing the first step of the tricarboxylic acid cycle in which acetyl coenzyme A and oxaloacetate are converted to citrate and coenzyme A. This enzyme is found in nearly all cells capable of oxidative metabolism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2016]

Cs Products(1)

mRNA Protein Name
NM_026444.4 NP_080720.1 citrate synthase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acyltransferase activity, acyl groups converted into alkyl on transfer IDA
IDA: Inferred from direct assay
18729827 MGI
enables citrate (Si)-synthase activity IDA
IDA: Inferred from direct assay
32212192 MGI
enables citrate (Si)-synthase activity IGI
IGI: Inferred from genetic interaction
31857692 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
31857692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

citrate synthase, mitochondrial

citrate (Si)-synthase

Related Agents

Approval
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109015 Tucidinostat Inhibitor 98.60% Unkown
HY-50935 Troglitazone 99.78% Unkown
HY-B0165A Pravastatin sodium 99.38% Yes
HY-16276 Osilodrostat Inhibitor 99.90% Yes
HY-100471 Esaxerenone Antagonist 99.93% Unkown
HY-17005 Olmesartan medoxomil Inhibitor 99.67% Unkown
HY-B0023 Azelnidipine Inhibitor 99.66% Unkown
HY-14818A Laninamivir octanoate Inhibitor 98.57% Unkown
HY-N7101 Cefpodoxime Proxetil Inhibitor 98.15% Unkown
HY-16276A Osilodrostat phosphate Inhibitor 99.35% Yes
HY-B0165 Pravastatin / Unkown
HY-B1595 Cefmetazole Inhibitor 98.82% Unkown
Clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-124526 Chiauranib Inhibitor 99.28% Phase 3
HY-16445 Sapacitabine Chemical 98.13% Phase 3
HY-100401 Pactimibe Inhibitor 99.98% Phase 3
HY-100401A Pactimibe sulfate Inhibitor ≥98.0% Phase 3
HY-141511 Coppersensor 1 ≥98.0% Phase 2
HY-14792B Inolitazone dihydrochloride Agonist 98.86% Phase 2
HY-106888A CS-722 / Phase 2
HY-137005 CS1 / Phase 2
HY-14783 Apricoxib Inhibitor / Phase 2
HY-14792 Inolitazone Agonist / Phase 2
HY-P6306A CS-6253 TFA 98.53% Phase 1
HY-100413 CS-526 Antagonist / Phase 1
HY-145995 CS12192 Inhibitor / Phase 1
HY-19404 Embeconazole Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99758 Nofazinlimab Inhibitor 98.83% Phase 3
HY-P99270 Tigatuzumab Inducer 99.90% Phase 2
Pre-clinical Phase
Bioactive Molecules (60)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1692 L-Methionine-DL-sulfoximine Inhibitor ≥98.0% Unkown
HY-148913 CS587 Inhibitor 98.18% Unkown
HY-B0165AR Pravastatin (sodium) (Standard) 98.10% Unkown
HY-148907 CS640 Inhibitor 99.43% Unkown
HY-P6306 CS-6253 98.84% Unkown
HY-124704 Chst15-IN-1 Inhibitor 98.09% Unkown
HY-150611 EGFR-IN-70 Inhibitor 99.16% Unkown
HY-P2727 Chondroitinase ABC / Unkown
HY-134136A Octanoyl coenzyme A lithium ≥98.0% Unkown
HY-14955 Managlinat dialanetil Inhibitor 98.13% Unkown
HY-P3522A REDV TFA 99.81% Unkown
HY-116228 Cadrofloxacin Inhibitor 98.21% Unkown
HY-14180 PHA 408 Inhibitor ≥98.0% Unkown
HY-15801 HG-14-10-04 Inhibitor 99.09% Unkown
HY-P3522 REDV 98.29% Unkown
HY-105268 AzddMeC Inhibitor 98.96% Unkown
HY-108493 CS-2100 Agonist 99.12% Unkown
HY-106174 Lapisteride Inhibitor ≥99.0% Unkown
HY-106850 3′-Azido-2′,3′-dideoxyuridine Inhibitor 99.11% Unkown
HY-111640 3'-Azido-3'-deoxy-5-methylcytidine Inhibitor 99.90% Unkown
HY-50935S Troglitazone-d4 98.19% Unkown
HY-D0798 Catechol violet ≥90.0% Unkown
HY-P10948A CS-VIP 8 TFA Inhibitor / Unkown
HY-106789 Plaunotol / Unkown
HY-106888 CS-722 Free base / Unkown
HY-109015S Tucidinostat-d4 Inhibitor / Unkown
HY-123022 Tomopenem Inhibitor / Unkown
HY-133606 3,4,5-Trichlorosyringol / Unkown
HY-134136 Octanoyl Coenzyme A / Unkown
HY-134136B Octanoyl coenzyme A triammonium / Unkown
HY-143445 EGFR-IN-48 Inhibitor / Unkown
HY-14818C Laninamivir octanoate hydrate / Unkown
HY-148863 Cavα2δ1&NET-IN-2 Inhibitor / Unkown
HY-14977 CS-0777-P Agonist / Unkown
HY-159936 CS4 / Unkown
HY-160929 Linafexor Agonist / Unkown
HY-163752 CS17919 Inhibitor / Unkown
HY-169247 Pam2CS-DMAPA / Unkown
HY-169427 FRF-06-057 Inhibitor / Unkown
HY-169982 EGFR-IN-136 Inhibitor / Unkown
HY-17005R Olmesartan medoxomil (Standard) Inhibitor 99.68% Unkown
HY-17005S Olmesartan medoxomil-d6 Inhibitor / Unkown
HY-173132 AKR1Cs-IN-1 Inhibitor / Unkown
HY-19633 CS-003 Free base Antagonist / Unkown
HY-19633A CS-003 / Unkown
HY-B0023S Azelnidipine-d7 Inhibitor / Unkown
HY-B0165AS Pravastatin-13C,d3 sodium / Unkown
HY-B0165S Pravastatin-d9 sodium / Unkown
HY-P10797 TAT-N24 Inhibitor / Unkown
HY-P10948 CS-VIP 8 Inhibitor / Unkown
HY-P1816 Fibronectin CS1 Peptide / Unkown
HY-P4021 Mca-KKEDVV-Abu-CS-Abu-S-(NO2)F-KK-NH2 / Unkown
HY-RS03221 CS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-14955A (Rac)-Managlinat dialanetil / Unkown
HY-169481 AP-1 Degrader / Unkown
HY-B0165CS Pravastatin-d3 sodium salt 99.02% Unkown
HY-N7101S1 Cefpodoxime Proxetil-d6 Inhibitor / Unkown
HY-RS16750 Cs Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23189 Cs Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-U00211 CS476 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cs NCBI NCBI:1431
Canis familiaris Cs NCBI NCBI:474403
Macaca fascicularis Cs NCBI NCBI:101926620
Susscrofa domestica Cs NCBI
Rattus norvegicus Cs NCBI NCBI:170587
Macaca mulatta Cs NCBI NCBI:709604