CS-6253 

CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease^[1][2][3].

CS-6253 (1 μM; 45 min-24 h) increases the release of cholesterol-containing microvesicles in ABCA1-expressing BHK cells, which is positively correlated with high-density lipoprotein biogenesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CS-6253 (75-225 mg/kg; intravenous injection; once every other day; 5 times in total) transiently increases plasma triglycerides, apolipoprotein E, and Aβ42/40 ratio, while reducing high-density lipoprotein cholesterol and total cholesterol in cynomolgus monkeys^[2].
CS-6253 (20 mg/kg; intraperitoneal injection; once every other day; 6 weeks) has improvement in a genetic risk model of Alzheimer’s disease^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3055.48

C₁₃₆H₂₂₈N₃₆O₄₃

1627911-44-7

Solid

White to off-white

Glu-Val-{Cit}-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-{Cit}-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser

EV-{Cit}-SKLEEWLAAL-{Cit}-ELAEELLARLKS

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Hafiane A, et al. ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism. Can J Cardiol. 2019 Jun;35(6):770-781.  [Content Brief]

  [2]. Noveir SD, et al. Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys. Alzheimers Res Ther. 2022 Jun 24;14(1):87.  [Content Brief]

  [3]. Boehm-Cagan A, et al. ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. J Alzheimers Dis. 2016 Oct 4;54(3):1219-1233.  [Content Brief]