Cryaa - crystallin, alpha A Gene

Mus musculus

Also known as Crya1; lop18; Acry-1; Crya-1; DAcry-1

Gene ID: 12954 | Gene type: protein coding

About Cryaa

Summary

This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein (sHSP) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. In mouse, deficiency in this gene is associated with smaller lenses and eyes and with increasing lens opacity with age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Cryaa Products(3)

mRNA	Protein	Name
NM_001278569.1	NP_001265498.1	alpha-crystallin A chain isoform 1
NM_001278570.1	NP_001265499.1	alpha-crystallin A chain isoform 3
NM_013501.3	NP_038529.1	alpha-crystallin A chain isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16439475	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	16799046	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	18056999	MGI
acts upstream of or within apoptotic process involved in morphogenesis	IGI IGI: Inferred from genetic interaction	16439475	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	12546709	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	18056999	MGI
acts upstream of or within lens development in camera-type eye	IGI IGI: Inferred from genetic interaction	16439475	MGI
acts upstream of or within lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	9023351	MGI
acts upstream of or within lens fiber cell morphogenesis	IMP IMP: Inferred from mutant phenotype	16799046	MGI
acts upstream of or within lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	8812430	MGI
acts upstream of or within microtubule-based process	IMP IMP: Inferred from mutant phenotype	12584250	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	16799046	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18191123	MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IGI IGI: Inferred from genetic interaction	16439475	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17893660	MGI
acts upstream of or within positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	9813033	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18056999	MGI
acts upstream of or within response to UV-A	IMP IMP: Inferred from mutant phenotype	9813033	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	17438522	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	18191123	MGI
acts upstream of or within tubulin complex assembly	IMP IMP: Inferred from mutant phenotype	16675842	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9813033	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-crystallin A chain

crystallin, alpha 1

lens opacity 18

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03206	CRYAA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20005	Cryaa Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26508	Cryaa Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cryaa	NCBI	NCBI:1409

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