Crx - cone-rod homeobox Gene

Mus musculus

Also known as Crx1

Gene ID: 12951 | Gene type: protein coding

About Crx

Summary

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and nuclear receptor binding activity. Involved in regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II and retina development in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; face; and nervous system. Used to study Leber congenital amaurosis 7. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Crx Products(2)

mRNA	Protein	Name
NM_001113330.1	NP_001106801.1	cone-rod homeobox protein isoform 2
NM_007770.4	NP_031796.1	cone-rod homeobox protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15689355	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20026326	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	14613968	MGI
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	16574740	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14613968	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12407160	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12407160	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16574740	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15689355	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15689355	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cone-rod homeobox protein

cone-rod homeobox containing

Crx Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86825	CRX Antibody (YA6518)	WB, IHC-P	Mouse, Rat

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111792	GSK1795091	Agonist	94.48%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153759	CRX000227	Modulator	≥95.0%	Unkown
HY-155801	CRX 527	Ligand	/	Unkown
HY-RS03203	CRX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118984	CRX-526	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crx	NCBI	NCBI:1406

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