2. Gene
  3. Col1a1 - collagen, type I, alpha 1 Gene

Col1a1 - collagen, type I, alpha 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cola1; Mov13; Cola-1; Mov-13; Col1a-1

Gene ID: 12842 | Gene type: protein coding

About Col1a1

Summary

This gene encodes the alpha-1 subunit of the fibril-forming type I Collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing. [provided by RefSeq, Nov 2015]

Col1a1 Products(1)

mRNA Protein Name
NM_007742.4 NP_031768.2 collagen alpha-1(I) chain preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables extracellular matrix structural constituent IDA
IDA: Inferred from direct assay
15383546 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
9213002 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7629088 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
14630726 MGI
acts upstream of or within bone trabecula formation IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
18248096 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
21625049 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
8130375 MGI
acts upstream of or within face morphogenesis IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within intramembranous ossification IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within negative regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
17018525 MGI
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
16311053 MGI
acts upstream of or within protein transport IMP
IMP: Inferred from mutant phenotype
8906420 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
8163675 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
18248096 MGI
Cellular Component GO Annotation Evidence Reference Source
part of collagen trimer IDA
IDA: Inferred from direct assay
7704020 MGI
part of collagen trimer IMP
IMP: Inferred from mutant phenotype
14630726 MGI
part of collagen type I trimer IDA
IDA: Inferred from direct assay
8018053 MGI
part of collagen type I trimer IMP
IMP: Inferred from mutant phenotype
7790374 MGI
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
34368841 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8018053 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
2209468 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
34368841 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(I) chain

alpha-1 type 1 collagen

alpha-1 type I collagen

procollagen, type I, alpha 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-47888 PLN-1474 Inhibitor 99.35% Unkown
HY-151932 FXR agonist 3 Agonist 95.94% Unkown
HY-120006A (rel)-AR234960 Agonist 98.95% Unkown
HY-146434 TGFβ-IN-2 Inhibitor 99.37% Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-154979 Anti-hepatic fibrosis agent 2 / Unkown
HY-155328 GK444 Inhibitor / Unkown
HY-172258 5-HT2B antagonist-2 Inhibitor / Unkown
HY-176737 TGF-β1/Smad-IN-1 Inhibitor / Unkown
HY-RS02970 COL1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16961 Col1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23404 Col1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col1a1 NCBI NCBI:1277