Celsr1 - cadherin, EGF LAG seven-pass G-type receptor 1 Gene

Mus musculus

Also known as Scy; Crsh; crash; Adgrc1

Gene ID: 12614 | Gene type: protein coding

About Celsr1

Summary

Predicted to enable calcium ion binding activity. Involved in establishment of planar polarity and neural tube closure. Acts upstream of or within several processes, including Rho protein signal transduction; apical protein localization; and morphogenesis of an epithelium. Located in membrane. Is expressed in several structures, including blastocyst; central nervous system; epithelium; primitive streak; and renal cortex. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (Cadherin EGF LAG seven-pass G-type receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Celsr1 Products(1)

mRNA	Protein	Name
NM_009886.2	NP_034016.2	cadherin EGF LAG seven-pass G-type receptor 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18849982	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	18849982	MGI
acts upstream of or within apical protein localization	IMP IMP: Inferred from mutant phenotype	16687519	MGI
acts upstream of or within establishment of body hair planar orientation	IMP IMP: Inferred from mutant phenotype	18849982	MGI
involved in establishment of planar polarity	IMP IMP: Inferred from mutant phenotype	12842012	MGI
acts upstream of or within establishment of planar polarity of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	12842012	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	18849982	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	12842012	MGI
acts upstream of or within lateral sprouting involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	10932191	MGI
acts upstream of or within motor neuron migration	IMP IMP: Inferred from mutant phenotype	20631168	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	17229766	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	12842012	MGI
acts upstream of or within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within protein localization involved in establishment of planar polarity	IDA IDA: Inferred from direct assay	18849982	MGI
acts upstream of or within regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20223754	MGI
acts upstream of or within wound healing	IGI IGI: Inferred from genetic interaction	20643356	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	20353824	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cadherin EGF LAG seven-pass G-type receptor 1

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

seven-pass transmembrane receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02465	CELSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18558	Celsr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25040	Celsr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Celsr1	NCBI	NCBI:9620

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