2. Gene
  3. Cdkn1a - cyclin-dependent kinase inhibitor 1A (P21) Gene

Cdkn1a - cyclin-dependent kinase inhibitor 1A (P21) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP20; Cdkn1; p21WAF; p21Cip1

Gene ID: 12575 | Gene type: protein coding

About Cdkn1a

Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at the G1 pahse. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA Polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of Apoptosis following Caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Cdkn1a Products(2)

mRNA Protein Name
NM_001111099.2 NP_001104569.1 cyclin-dependent kinase inhibitor 1
NM_007669.5 NP_031695.1 cyclin-dependent kinase inhibitor 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cyclin binding IDA
IDA: Inferred from direct assay
12124778 MGI
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
12130539 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11022036 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
12952892 MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
IDA: Inferred from direct assay
10710310 MGI
involved in cellular response to UV-B IDA
IDA: Inferred from direct assay
25329316 MGI
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
26102367 MGI
acts upstream of or within cellular response to gamma radiation IDA
IDA: Inferred from direct assay
10710310 MGI
acts upstream of or within cellular senescence IGI
IGI: Inferred from genetic interaction
11551927 MGI
acts upstream of or within epidermis development IGI
IGI: Inferred from genetic interaction
11551927 MGI
acts upstream of or within fibroblast proliferation IGI
IGI: Inferred from genetic interaction
26334721 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
24380855 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
26334721 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
12952892 MGI
acts upstream of or within keratinocyte differentiation IGI
IGI: Inferred from genetic interaction
11551927 MGI
acts upstream of or within keratinocyte proliferation IGI
IGI: Inferred from genetic interaction
11551927 MGI
involved in negative regulation of cardiac muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
24380855 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12759355 MGI
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12130539 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11981756 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
36689330 MGI
acts upstream of or within oncogene-induced cell senescence IGI
IGI: Inferred from genetic interaction
11551927 MGI
acts upstream of or within oncogene-induced cell senescence IMP
IMP: Inferred from mutant phenotype
11551927 MGI
acts upstream of or within positive regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
12970760 MGI
acts upstream of or within positive regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
12759355 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
11981756 MGI
acts upstream of or within regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
11981756 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
12588994 MGI
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
24380855 MGI
acts upstream of or within regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
11981756 MGI
acts upstream of or within regulation of mitotic cell cycle IDA
IDA: Inferred from direct assay
15831459 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11981756 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
12952892 MGI
involved in tissue regeneration IMP
IMP: Inferred from mutant phenotype
20231440 MGI
involved in wound healing IMP
IMP: Inferred from mutant phenotype
20231440 MGI
Cellular Component GO Annotation Evidence Reference Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
12970760 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11254359 MGI
located in cytosol IDA
IDA: Inferred from direct assay
15964824 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
12970760 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11254359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase inhibitor 1

CDK-interacting protein 1

melanoma differentiation-associated protein

Cdkn1a Antibodies

Cat. No. Product Name Application Reactivity
HY-P87164 p21 Antibody (YA6857) WB, ICC/IF, IHC-P, FC Mouse

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10587 BIX-01294 98.44% Unkown
HY-161138 WK369 99.89% Unkown
HY-162384 EPIC-0628 Inhibitor 98.93% Unkown
HY-161024 AC1Q3QWB Inhibitor 99.39% Unkown
HY-108239 BIX-01294 trihydrochloride 99.68% Unkown
HY-148408 SIRT2-IN-11 Inhibitor 99.94% Unkown
HY-RS02410 CDKN1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123994 Tenovin-D3 hydrochloride Inhibitor / Unkown
HY-N7175 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol Inducer / Unkown
HY-RS02411 Cdkn1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16696 Cdkn1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn1a NCBI NCBI:1026