Cdk5r1 - cyclin-dependent kinase 5, regulatory subunit 1 (p35) Gene

Mus musculus

Also known as p25; p35; Cdk5r; D11Bwg0379e

Gene ID: 12569 | Gene type: protein coding

About Cdk5r1

Summary

Enables several functions, including HSP90 protein binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and enzyme binding activity. Involved in several processes, including Ephrin Receptor signaling pathway; nervous system development; and regulation of Cytoskeleton organization. Acts upstream of or within several processes, including G1 to G0 transition involved in cell differentiation; nervous system development; and serine phosphorylation of STAT protein. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CDK5R1 (cyclin dependent kinase 5 regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5r1 Products(1)

mRNA	Protein	Name
NM_009871.3	NP_034001.1	cyclin-dependent kinase 5 activator 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	17517623	MGI
enables actin binding	IPI IPI: Inferred from physical interaction	19118186	MGI
enables actin filament binding	IPI IPI: Inferred from physical interaction	19118186	MGI
enables cyclin-dependent protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	11517264	MGI
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	19118186	MGI
enables protease binding	IPI IPI: Inferred from physical interaction	19118186	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11276227	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19118186	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G1 to G0 transition involved in cell differentiation	IMP IMP: Inferred from mutant phenotype	21566658	MGI
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	10545161	MGI
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	10545161	MGI
involved in brain development	IMP IMP: Inferred from mutant phenotype	10545161	MGI
acts upstream of or within cerebellum development	IGI IGI: Inferred from genetic interaction	11517264	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	11226314	MGI
involved in cerebral cortex radially oriented cell migration	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in ephrin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17143272	MGI
acts upstream of or within hippocampus development	IGI IGI: Inferred from genetic interaction	11517264	MGI
acts upstream of or within layer formation in cerebral cortex	IGI IGI: Inferred from genetic interaction	11517264	MGI
involved in neuron cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	10753743	MGI
involved in neuron migration	IDA IDA: Inferred from direct assay	9010203	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	11226314	MGI
acts upstream of or within positive regulation of protein kinase activity	IGI IGI: Inferred from genetic interaction	11517264	MGI
acts upstream of or within positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	18054859	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	17143272	MGI
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20624590	MGI
acts upstream of or within serine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	15096606	MGI
acts upstream of or within superior olivary nucleus maturation	IGI IGI: Inferred from genetic interaction	11517264	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15123626	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15096606	MGI
part of protein kinase 5 complex	IPI IPI: Inferred from physical interaction	18325333	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclin-dependent kinase 5 activator 1

CDK5 activator 1	TPKII regulatory subunit
cyclin-dependent kinase 5 regulatory subunit 1	cyclin-dependent kinase 5, regulatory subunit (p35) 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02387	CDK5R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20536	Cdk5r1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27045	Cdk5r1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk5r1	NCBI	NCBI:8851

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