Runx3 - runt related transcription factor 3 Gene

Mus musculus

Also known as Rx3; AML2; Cbfa3; Pebp2a3

Gene ID: 12399 | Gene type: protein coding

About Runx3

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of alpha-beta T cell differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; hair follicle morphogenesis; and positive regulation of extrinsic apoptotic signaling pathway. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study asthma and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); female reproductive organ Cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder Cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Runx3 Products(2)

mRNA	Protein	Name
NM_001369050.1	NP_001355979.1	runt-related transcription factor 3 isoform 2
NM_019732.2	NP_062706.2	runt-related transcription factor 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12807883	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17352693	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17352693	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20399120	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12352981	MGI
acts upstream of or within cell maturation	IGI IGI: Inferred from genetic interaction	15107406	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	22916278	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	15937937	MGI
involved in negative regulation of CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	18258917	MGI
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	11955451	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	11955451	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17352693	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	12352981	MGI
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	18258917	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11955451	MGI
acts upstream of or within type II interferon production	IDA IDA: Inferred from direct assay	20399120	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	17352693	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15514019	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

runt-related transcription factor 3

CBF-alpha-3	PEA2-alpha C
PEBP2-alpha C	SL3-3 enhancer factor 1 alpha C subunit
SL3/AKV core-binding factor alpha C subunit	acute myeloid leukemia 2 protein
core binding factor alpha 3	core-binding factor subunit alpha-3
oncogene AML-2	polyomaviru

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12352	RUNX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20100	Runx3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26603	Runx3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Runx3	NCBI	NCBI:864

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