2. Gene
  3. Casq1 - calsequestrin 1 Gene

Casq1 - calsequestrin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CSQ; CSQ1; sCSQ; CSQ-1

Gene ID: 12372 | Gene type: protein coding

About Casq1

Summary

Enables calcium ion binding activity. Involved in sarcomere organization. Acts upstream of or within endoplasmic reticulum organization; regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion; and response to heat. Located in mitochondrial matrix and sarcoplasmic reticulum lumen. Is expressed in several structures, including diaphragm; heart; lung; musculature; and myotome. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CASQ1 (calsequestrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Casq1 Products(1)

mRNA Protein Name
NM_009813.2 NP_033943.2 calsequestrin-1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
7945294 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
17627988 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
12419813 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
17627988 MGI
acts upstream of or within regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IMP
IMP: Inferred from mutant phenotype
17627988 MGI
involved in regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IMP
IMP: Inferred from mutant phenotype
22049211 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
19237502 MGI
involved in sarcomere organization IMP
IMP: Inferred from mutant phenotype
22049211 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
7945294 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
7945294 MGI
located in sarcoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
16600288 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calsequestrin-1

calmitine

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01972 CASQ1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19990 Casq1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26494 Casq1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casq1 NCBI NCBI:844