Bach2 - BTB and CNC homology, basic leucine zipper transcription factor 2 Gene

Mus musculus

Also known as E030004N02Rik

Gene ID: 12014 | Gene type: protein coding

About Bach2

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in import into nucleus and negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; limb bud; reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in immunodeficiency 60. Orthologous to human BACH2 (BTB domain and CNC homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Bach2 Products(1)

mRNA	Protein	Name
NM_001109661.1	NP_001103131.1	transcription regulator protein BACH2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8887638	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8887638	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8887638	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8887638	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8887638	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in import into nucleus	IMP IMP: Inferred from mutant phenotype	26021350	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8887638	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8887638	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8887638	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription regulator protein BACH2

BTB and CNC homolog 2	BTB and CNC homology 2
Transcription regulator protein BACH2 (BTB and CNC homolog 2)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS19986	Bach2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01340	BACH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26490	Bach2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bach2	NCBI	NCBI:60468

Name
Email *

	Sorry, but the email address you supplied was invalid.