2. Gene
  3. Aqp4 - aquaporin 4 Gene

Aqp4 - aquaporin 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as WCH4

Gene ID: 11829 | Gene type: protein coding

About Aqp4

Summary

This gene encodes a member of the Aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant Aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]

Aqp4 Products(9)

mRNA Protein Name
NM_001308641.1 NP_001295570.1 aquaporin-4 isoform M23
NM_001308642.1 NP_001295571.1 aquaporin-4 isoform M23
NM_001308643.1 NP_001295572.1 aquaporin-4 isoform M23
NM_001308644.1 NP_001295573.1 aquaporin-4 isoform M23
NM_001308645.1 NP_001295574.1 aquaporin-4 isoform M23
NM_001308646.1 NP_001295575.1 aquaporin-4 isoform M23
NM_001308647.2 NP_001295576.1 aquaporin-4 isoform M23
NM_001317729.1 NP_001304658.1 aquaporin-4 isoform M1x
NM_009700.3 NP_033830.2 aquaporin-4 isoform M1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21262839 MGI
enables water channel activity IDA
IDA: Inferred from direct assay
8660998 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cerebrospinal fluid circulation IMP
IMP: Inferred from mutant phenotype
22896675 MGI
involved in cerebrospinal fluid secretion IMP
IMP: Inferred from mutant phenotype
30293570 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
10613915 MGI
involved in intracellular water homeostasis IDA
IDA: Inferred from direct assay
18286643 MGI
involved in multicellular organismal-level water homeostasis IDA
IDA: Inferred from direct assay
27751903 MGI
acts upstream of or within multicellular organismal-level water homeostasis IMP
IMP: Inferred from mutant phenotype
12034763 MGI
acts upstream of or within renal water absorption IGI
IGI: Inferred from genetic interaction
10662735 MGI
acts upstream of or within renal water absorption IMP
IMP: Inferred from mutant phenotype
10662735 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
11406631 MGI
involved in water transport IDA
IDA: Inferred from direct assay
18286643 MGI
acts upstream of or within water transport IMP
IMP: Inferred from mutant phenotype
10613915 MGI
Cellular Component GO Annotation Evidence Reference Source
located in astrocyte end-foot IDA
IDA: Inferred from direct assay
22896675 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10021464 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12673830 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18718702 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16582023 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
29055082 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aquaporin-4

mercurial-insensitive water channel

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-115460 AER-271 98.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W008574 TGN-020 99.44% Unkown
HY-W008574A TGN-020 sodium 99.96% Unkown
HY-W176557 TGN-073 99.53% Unkown
HY-N10756 Hyp9 Agonist 99.90% Unkown
HY-P10936A AQP4 (201-220) TFA 98.01% Unkown
HY-RS00876 AQP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-157226 ORI-TRN-002 Inhibitor / Unkown
HY-P10936 AQP4 (201-220) / Unkown
HY-P10937 AQP4 (205-215) / Unkown
HY-P10937A AQP4 (205-215) TFA / Unkown
HY-RS16702 Aqp4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23136 Aqp4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aqp4 NCBI NCBI:361