2. Gene
  3. Aqp2 - aquaporin 2 Gene

Aqp2 - aquaporin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as cph; jpk; AQP-CD; WCH-CD

Gene ID: 11827 | Gene type: protein coding

About Aqp2

Summary

Enables water channel activity. Acts upstream of or within cellular response to water deprivation; metanephric collecting duct development; and renal water transport. Located in several cellular components, including apical plasma membrane; perinuclear region of cytoplasm; and recycling endosome. Is expressed in inner ear; metanephros; vestibulo-cochlear ganglion; and vestibulocochlear nerve cochlear component. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Orthologous to human AQP2 (Aquaporin 2). [provided by Alliance of Genome Resources, Apr 2022]

Aqp2 Products(1)

mRNA Protein Name
NM_009699.3 NP_033829.3 aquaporin-2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables water channel activity IDA
IDA: Inferred from direct assay
10191086 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to water deprivation IDA
IDA: Inferred from direct assay
10191086 MGI
involved in metanephric collecting duct development IEP
IEP: Inferred from expression pattern
18618131 MGI
acts upstream of or within renal water homeostasis IDA
IDA: Inferred from direct assay
27402760 MGI
acts upstream of or within renal water transport IMP
IMP: Inferred from mutant phenotype
3184310 MGI
acts upstream of or within water transport IDA
IDA: Inferred from direct assay
10191086 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10322639 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
27402760 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
18505797 MGI
located in lumenal side of membrane IDA
IDA: Inferred from direct assay
17409310 MGI
located in membrane IDA
IDA: Inferred from direct assay
15632412 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
27402760 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10191086 MGI
located in recycling endosome IDA
IDA: Inferred from direct assay
10191086 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aquaporin-2

ADH water channel

AQP-2

aquaporin-CD

collecting duct water channel protein

water channel protein for renal collecting duct

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N2057 Steviol 99.69% Unkown
HY-RS00874 AQP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18336 Aqp2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24815 Aqp2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W288951 FMP-API-1 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aqp2 NCBI NCBI:359