Nr0b2 - nuclear receptor subfamily 0, group B, member 2 Gene

Rattus norvegicus

Also known as Shp

Gene ID: 117274 | Gene type: protein coding

About Nr0b2

Summary

Enables peroxisome proliferator activated receptor binding activity; retinoid X receptor binding activity; and Thyroid Hormone Receptor binding activity. Involved in several processes, including animal organ regeneration; bile acid and bile salt transport; and positive regulation of Insulin secretion. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetes mellitus; and intrahepatic cholestasis. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr0b2 Products(1)

mRNA	Protein	Name
NM_057133.1	NP_476474.1	nuclear receptor subfamily 0 group B member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	9003453	RGD
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	9003453	RGD
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	9003453	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	9003453	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10648597	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	15904869	RGD
involved in bile acid and bile salt transport	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15860571	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15860571	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17259388	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to glucose	IMP IMP: Inferred from mutant phenotype	17259388	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	27939985	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	10648597	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor subfamily 0 group B member 2

orphan nuclear receptor SHP

small heterodimer partner homologue

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09526	NR0B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21668	Nr0b2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28186	Nr0b2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr0b2	NCBI	NCBI:8431

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